Effect of Ethnicity on the Clinical Presentations of Women With Polycystic Ovary Syndrome: A 20-Year Retrospective Cohort Study

March 2013 in “ Endocrine Abstracts ”

Hamidreza Mani, Miles Levy, Melanie J Davies, Danielle Morris, Laura Gray, Kamlesh Khunti, Trevor A. Howlett

polycystic ovary syndrome PCOS androgenic alopecia hirsutism androgenic criteria anovulatory criteria

TLDR Ethnicity affects how polycystic ovary syndrome shows up in women, with white women having higher metabolic risks but less diabetes, and South Asian women showing more androgenic symptoms and being younger at presentation.

The retrospective cohort study conducted from 1988 to 2009, involving 2207 women with polycystic ovary syndrome (PCOS), found that ethnicity significantly affected the clinical and phenotypic presentation of PCOS. Of the total participants, 684 (30%) were South Asian (SA). White women showed a higher metabolic risk profile, including hypertension, smoking, and higher BMI, but less diabetes. In contrast, SA women presented more androgenic criteria (including hirsutism and androgenic alopecia) and less anovulatory criteria, were younger at presentation, and came from more deprived backgrounds. These findings suggested that understanding these ethnic differences could help tailor appropriate management for different patient groups with PCOS.

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