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In this study, intravital microscopy in live mice showed that apoptosis in hair follicle regression may be driven by apoptotic cells inducing neighboring cell death, with stem cells likely providing a pro-survival signal.

In this case study, researchers documented a Chinese boy with hair color changing to red and identified MC1R genetic mutations as the cause, rather than zinc deficiency, enhancing our understanding of hair heterochromia due to genetic factors.

At a workshop highlighted during the 2025 ESPCR meeting, researchers discussed the challenges and variability in culturing skin-related cells, identifying key factors such as media composition and species differences that affect experimental reproducibility, and emphasized the importance of transparent practices to advance pigment cell research.

This case report describes the unexpected hair repigmentation surrounding a scalp tumor in a 74-year-old man, suggesting a potential link between the carcinoma and changes in hair pigmentation.

This study suggests that 3,4,5-tri-O-caffeoylquinic acid activates β-catenin to enhance pigmentation in mouse hair follicles, human melanocytes, and melanoma cells during the hair cycle's growth phase.

Stress can cause hair to turn gray by depleting stem cells.

This study found that melanin extracted from cuttlefish ink provided significant protection against UV radiation damage to human hair, suggesting its potential as a photoprotective agent in hair-care products.

This study suggests that melatonin plays a role in hair follicle function by modulating growth and pigmentation, and it may act as a protective agent in active hair growth phases.

Thick scalp melanoma can be hard to diagnose because it often looks like other skin conditions.

This study found that inhibiting PKC-β activity with bisindolylmaleimide reduces pigmentation in the skin and hair of guinea pigs and mice by preventing tyrosinase activation.

This study found that physoxia improved hair follicle functions in co-cultures of dermal papilla cells and melanocytes by enhancing their biological activities and promoting hair growth and pigmentation.

This review discusses transplantation of melanocyte stem cells for vitiligo treatment and reports no new clinical results; it suggests the procedure could be effective in reactivating melanocyte precursors for repigmentation.

This study reviewed 41 cases of lichen planus pigmentosus in patients from southeastern Tunisia, highlighting its prevalence among older individuals and notable differences compared to patterns observed in an Indian cohort.

This review discusses the roles of PAX3 in melanocyte development and melanoma progression but reports no new experimental results; the authors propose it as a key regulatory factor and call for further investigation.

This study found that a combination of low-fluence Q-switched 1064 nm Nd:YAG laser, hydroquinone cream, and oral tranexamic acid showed promising results for Riehl’s melanosis in Asian patients, with no serious adverse events reported.

The digital system for measuring melasma shows promise but needs more development for better accuracy and automation.

Light skin shows more inflammation from sun exposure than dark skin.

This review summarizes recent pathological discoveries related to chemical leukoderma and chemical-induced vitiligo, especially focusing on rhododendrol, a chemical responsible for a significant outbreak affecting around 20,000 individuals in Japan and Asia.

This study reviews the role of the KIT ligand and receptor pathway in managing melanocyte and mast cell-related skin diseases, examining how its regulation can lead to potential therapies for conditions like vitiligo, melanoma, and mastocytosis. Results are not reported.

This study found that Plerixafor, a CXCR4 antagonist, promotes melanogenesis in melanocytes by increasing MITF and tyrosinase expression and enhancing melanocyte migration, and it effectively restores pigmentation in a mouse depigmentation model without toxicity, highlighting its potential for treating pigmentary disorders.

This review discusses the mechanisms of hair repigmentation and reports no clinical results; the authors suggest further research into topical treatments for reversing gray hair.

This study found that melanin granules in black human hair are key dyeing regions for oxidative hair coloring, as confirmed by nanoscale mass spectrometry analysis detecting deuterium ions.

Dermoscopy greatly improves melanoma diagnosis and reduces unneeded surgeries.

In this study, mangosteen pericarp water extract was found to significantly promote hair dermal papilla cell proliferation and enhance melanin synthesis in vitro, surpassing known melanogenic agents such as α-melanocyte stimulating hormone and forskolin in potency.

This study demonstrated that a c-Kit-CreER-driven mouse model confirms melanocyte stem cells as a genuine source of melanoma, paralleling human melanoma in heterogeneity and gene signatures.

This review discusses the impact of melatonin and its metabolites on skin aging, summarizing how they may serve as "aging neutralizers" through their anti-oxidative and anti-inflammatory properties, but reports no new clinical results.

This study found that kojic acid and niacinamide were the most effective inhibitors of UVB-induced NF-κB activation and IL-6 secretion in HaCaT keratinocytes, suggesting a role in modulating melanotrophic factor synthesis.

This study examined the factors contributing to gray hair, such as genetics and lifestyle, and found that while graying correlates with some health conditions, it is primarily a physiological process rather than a pathological one.

This study found that autologous noncultured epidermal suspension transplantation improved leukotrichia in 88.1% of treated vitiligo lesions without significant adverse events.

This review discusses the genetic and environmental factors involved in the development of skin cancers like squamous cell carcinoma, basal cell carcinoma, and melanoma, but does not report new clinical findings.