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research Ox40-Cre–mediated deletion of BRD4 reveals an unexpected phenotype of hair follicle stem cells in alopecia
In this study, conditional deletion of BRD4 in OX40-expressing cells of mice led to alopecia, dermatitis, and loss of hair follicle stem cell function, revealing BRD4's role in skin inflammation and stem cell regulation.
research Traditional Chinese Medicine Treatment for Androgenetic Alopecia Based on Animal Experiments: A Systematic Review and Meta-Analysis
This study found that Traditional Chinese Medicine increased hair follicle numbers and improved hair growth metrics in androgenetic alopecia rodent models, suggesting potential benefits linked to reduced serum testosterone levels.
research Using artificial intelligence to analyze publicly available social media posts to understand patient perspectives toward specific treatments of alopecia areata
This study analyzed social media posts on alopecia areata treatments and found that while most reported perceived improvement, many treatments, particularly dexamethasone, were associated with underlying negative emotions.
research Patient Counselling and Medicolegal Aspects of Hair Transplant Surgery
This article reviews the importance of informed consent in hair transplantation and emphasizes its role in patient satisfaction and reducing legal claims, without reporting new research findings.
research γδ T cells mediate a requisite portion of a wound healing response triggered by cutaneous poxvirus infection
This study found that skin-resident and recruited γδ T cells play a crucial role in an early wound healing response following cutaneous vaccinia virus infection, rather than in controlling virus replication.
research American Society for Laser Medicine and Surgery 2019 Late Breaking Abstracts
This article contains the late-breaking abstracts from the 39th Annual Conference of the American Society for Laser Medicine and Surgery and does not present new research results.
research A brief lightening on medicinal activity and Pharmacological profile of plant Eclipta prostrata: A Review
This study reviews the pharmacological properties of the plant Eclipta prostrata, highlighting its potential in treating various conditions including wound healing, diabetes, liver protection, alopecia, gum disease, cancer prevention, bone health, and antimicrobial effects, alongside its traditional use in tropical regions.
research Proceedings from the 7th Annual University of Calgary Leaders in Medicine Research Symposium
This article summarizes the 7th Annual Research Symposium of the Leaders in Medicine program at the University of Calgary, highlighting student research presentations and the program's goals, but reports no new research findings.
research American Society for Laser Medicine and Surgery - 2018 Late-Breaking Abstracts
This review summarizes late-breaking abstracts from the American Society for Laser Medicine and Surgery, 2018, and reports no new clinical findings.
research Combination of Western Medicine and Traditional Chinese Medicine for Treatment of Malignant Bone and Soft Tissue Tumors
This study found that combining intra-arterial chemotherapy with Traditional Chinese Medicine may improve response rates in malignant bone and soft tissue tumor treatment while also managing specific side effects.
research Four Cases of Androgenetic Alopecia Patient using Korean Medicine Treatment and Western Treatment
This case study reported improvements in alopecia symptoms in patients taking finasteride for over a year when treated with the herbal medicine Gagamcheongyoung-tang.
research The neurosteroid metabolite of progesterone, 3α‐OH‐dihydroprogesterone (3α‐OH‐DHP), is required for attenuated baroreflex mediated sympathoexcitation in pregnancy
In this study, chronic finasteride administration in near-term pregnant rats restored baroreflex control of renal sympathetic nerve activity to levels observed in non-pregnant rats.
research Evaluation of Two Medium-Depth Peels: Glycolic Acid 70% Versus Trichloroacetic Acid 35%: A Histological and Immunohistochemichal Study on Rat Skin
This study observed that both TCA (35%) and GA (70%) chemical peels improved skin morphology and stimulated bulge stem cells in albino rats, with no significant difference between the two agents.
research Androgen receptor-mediated gene activation in prostate cancer cells
This study provides insight into AR-mediated gene activation and the molecular mechanisms of prostate cancer progression and drug resistance, identifying potential avenues for developing new therapies.
research The Effects of a Powder of the Fruiting Body of Commercial Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (W.Curt.:Fr.) P.Karts.,] on Hypercholesterolemic Rat Skin, Applied With a Topical Application of Benzo(a)pyrene
This study found that Ganoderma lucidum fruiting body powder improved cholesterol profiles and hair follicle health in rats exposed to a tumor-promoting agent, suggesting potential chemopreventive properties against skin abnormalities.
research FACILE WATER MEDIATED SYNTHESIS OF FINASTERIDE FORM-I, AN AZAANDROSTANE STEROID
This study reports a new method for selectively synthesizing finasteride Form-I in good yield using water as an ecofriendly solvent at room temperature.
research Studies on the effects of medicinal plant extracts on the hair growth stimulation
This study found that several natural extracts, including Polygonum multiflorum Thunb and Terminalia chebula Retz., promoted hair growth in mouse models but showed limited effectiveness on human hair growth in vitro.
research Effect of 55 Chinese herbal medicines on the biology of mouse vibrissa fcllicles in vitro
In this study, certain Chinese herbal medicines were found to significantly stimulate or inhibit hair growth in an in vitro organ culture model of mouse vibrissa follicles.
research Cyclic Nucleotides and the Mediation of Melatonin-induced Inhibition of Melanogenesis in Mammals
Melatonin stops melanin production after tyrosinase action, with cyclic GMP mimicking this effect.
research Tolerogenic dendritic cell-conditioned medium promotes hair growth by modulating follicular microenvironment in a DHT-treated mouse model
This study found that administering tolerogenic dendritic cell-conditioned medium to dihydrotestosterone-treated mice promoted hair regrowth by modulating the follicular microenvironment, reducing pro-inflammatory cytokines, and activating key signaling pathways, highlighting its potential as a treatment for androgenetic alopecia.
research Assessing Alopecia Areata Management in Poland: Challenges in Medical Practices and Patient Care
In this study, researchers found that the management of alopecia areata in Poland is inadequate, despite following international guidelines, due to limited access to advanced treatments and insufficient use of severity assessments and psychosocial support.
research From Anti-Aging Medicine to Precision Healthspan Pharmacology: Evidence Domains, Monitoring Requirements, and Practical Boundaries
This source redefines anti-aging medicine as "precision healthspan pharmacology," suggesting that rather than just treating diseases or accepting aging, pharmacology should focus on expanding functional capacity across various health domains, while emphasizing the importance of fundamental physiological and psychosocial health factors.
research Radiofrequency Microneedling-Mediated Enhancement in Percutaneous Delivery of Topical Triamcinolone Acetonide: An In Vivo Quantitative Study
This study found that radiofrequency microneedling significantly enhanced the absorption of topical triamcinolone acetonide, with insertion depth being more influential than RF energy levels.
research Dose-Dependent Increases in Carotid Intima-Media Thickness Associated with Oral Minoxidil but Not Dutasteride in Healthy Young Males: A Randomized Controlled Pharmacological Trial
This study found that in healthy young men, oral minoxidil at 5 mg/day led to increased carotid intima-media thickness and vascular aging, suggesting potential cardiovascular side effects at higher doses. A dose-dependent effect was observed, while dutasteride displayed a favorable vascular profile without significant changes.
research Emerging concepts: regenerative medicine in dermatology
research An ethnobotanical review of medicinal plants used for treating hemorrhoids in Thailand
In this study, a comprehensive literature review identified 181 plant species traditionally used for hemorrhoid treatment in Thailand, highlighting key species with pharmacological activities such as anti-inflammatory and analgesic effects, which are poised for potential pharmaceutical development.
research Health consequences of anabolic steroids: a sexual-medicine perspective
This review outlines the major health consequences of anabolic-androgenic steroid abuse, with a focus on sexual and reproductive issues, and suggests management prioritizes cessation and relapse prevention due to lack of robust randomized trials.
research High prevalence of poly cystic ovary syndrome among young Saudi medical students: an observational cross-sectional study
In this study, young female medical students at King Saud University reported a higher prevalence of physician-diagnosed PCOS compared to similar Western populations, and hirsutism was notably associated with the condition, highlighting the need for early screening and health education.
research Decoding precision medicine in prediabetes: a citespace-based bibliometric analysis of current trends and future directions
In this bibliometric analysis, researchers observed that precision medicine approaches, such as individualized interventions and biomarker-guided subtyping, are increasingly integrated into prediabetes research, highlighting shifts toward using multi-omics data and artificial intelligence for patient stratification and prevention strategies.