The Effects of a Powder of the Fruiting Body of Commercial Lingzhi or Reishi Medicinal Mushroom Ganoderma Lucidum on Hypercholesterolemic Rat Skin, Applied With a Topical Application of Benzo(a)pyrene

    January 2010 in “ International journal of medicinal mushrooms ”
    Choong Yew Keong, Tong Chow Chin, Nor Aini Umar, Noordin Mohamed Mustapha, Sulaila Mohamad
    TLDR Ganoderma lucidum powder may help prevent skin cancer and lower cholesterol.
    The study investigated the anti-tumor effects of Ganoderma lucidum fruiting body powder on hypercholesterolemic Sprague Dawley rats exposed to benzo(a)pyrene. Over 6 months, 24 rats were divided into four groups: Control, 1% cholesterol diet (Chol), 1% G. lucidum powder (GF), and cholesterol with G. lucidum powder (Chol+GF). Results showed that the Chol+GF group had lower body weight compared to the Chol group. The GF group exhibited significantly lower serum total cholesterol, triglycerides, and low-density lipoprotein levels, but higher high-density lipoprotein cholesterol than the Chol group. Malondialdehyde levels were significantly reduced in the Chol+GF group. Histological analysis revealed normal hair growth and follicles in the GF and Chol+GF groups, suggesting that G. lucidum powder might be an effective cancer chemopreventive agent for skin.
    Discuss this study in the Community →