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Orphan drug benefit scores in Germany are influenced by phase III data and lack of alternatives, but not linked to price or discounts.

The secretions of mesenchymal stem cells could be used for healing without using the cells themselves.

Hair follicle development is controlled by interactions between skin tissues and specific molecular signals.

Keratins help protect cells, aid in cancer diagnosis, and influence cancer behavior and treatment.

Targeting colon cancer stem cells might lead to better treatment results.

The document likely offers guidance on treating a woman's excessive hair growth, considering her symptoms and obesity.

Chemotherapy can cause skin problems like hair loss, mouth sores, and skin darkening, and recognizing these can affect treatment decisions.

Male and female skin differ due to hormones, affecting conditions like hair loss, acne, and skin cancer, and suggesting a need for gender-specific treatments.

Cancer cells often have more copies of TERT and TERC genes, which helps them grow and could affect patient outcomes.

Some viruses can cause cancer by changing cell processes and avoiding the immune system; vaccines and targeted treatments help reduce these cancers.

Estrogen replacement can improve skin health in menopausal women but doesn't reverse sun damage or prevent hair loss.

Estrogen loss during menopause worsens skin health, but hormone replacement therapy may improve it, though more research is needed.

Understanding how cells die in the skin is important for treating skin diseases and preventing hair loss.

Hair grows faster in the morning and is more vulnerable to damage from radiation due to the internal clock in hair follicle cells.

Understanding the mouse hair cycle is crucial for cancer research.

The document concludes that understanding the sebaceous gland's development and function is key to addressing related skin diseases and aging effects.

People with alopecia areata often have other health issues like skin diseases, metabolic syndrome, stomach infections, lupus, anemia, thyroid problems, mental health issues, vitamin D deficiency, and hearing and eye problems.

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

Voriconazole can cause serious side effects, especially in long-term use.

The document concludes that accurate diagnosis and personalized treatment are important for skin problems in women with PCOS.

Targeted cancer therapies often cause skin reactions, so dermatologists must manage these effects.

Mice studies show that Protein Phosphatase 2A is crucial for cell growth, development, and disease prevention.

Women with PCOS often have skin problems like excessive hair, acne, hair loss, and dark patches, which can be treated with hormonal and non-hormonal therapies.

Shrinking skin cancer increases the chance of cancer in nearby lymph nodes.

Hirsutism is excessive hair growth in women often caused by polycystic ovarian syndrome, and identifying the cause is important for managing associated health risks.

European guidelines recommend regular eye and ear exams, skin care, vitamin D supplements, and cautious use of medications for managing congenital ichthyoses.

High-frequency ultrasonography is a useful but underused tool in dermatology for assessing skin cancers, monitoring diseases, and evaluating treatments.

Epidermal stem cells could lead to new treatments for skin and hair disorders.

Apoptosis is crucial for healthy skin and treating skin diseases.

Multiphoton microscopy is a promising tool for detailed skin imaging and could improve patient care if its challenges are addressed.