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Dermal stem cells help regenerate hair follicles and heal skin wounds.

The environment around the time of conception can change the VTRNA2-1 gene in a way that lasts for years and may affect disease risk.

Cyclosporine is effective for skin conditions but has declined in use due to toxicity concerns.

Hair follicles help skin immune recovery after UVB exposure.

UV light helped human hair transplants survive in mice without broad immunosuppression.

UVB exposure in human skin causes macrophages to produce more IL-10 and less IL-12, leading to immunosuppression.

Alopecia areata can be triggered by specific immune cells without genetic or environmental factors.

MDSC-Exo can treat autoimmune alopecia areata and promote hair regrowth in mice.

Non-coding RNAs could help detect and treat radiation damage.

Unconventional lymphocytes are important for quick immune responses and healing of skin and mucosal barriers.

Thyroid disease can cause skin, hair, and nail problems, and treating the thyroid condition often improves these symptoms.

The Wnt/β-catenin pathway is important for body functions and diseases, and targeting it may treat conditions like cancer, but with safety challenges.

Hair follicles help attract immune cells to the skin during stress.

Alopecia areata is an autoimmune disease where T cells attack hair follicles.

Hair follicle-derived IL-7 and IL-15 are crucial for maintaining skin-resident memory T cells and could be targeted for treating skin diseases and lymphoma.

Innate lymphoid cells help control skin bacteria by regulating sebaceous glands.

Loss of a specific protein in skin cells causes symptoms similar to psoriasis.

RXRα is crucial for proper immune response and links diet to immune function.

Blocking JAK3 signaling can reverse hair loss from alopecia areata.

GRHL3 is important for controlling gene activity in skin cells during different stages of their development.

Lipocalin-Type Prostaglandin D2 Synthase (L-PGDS) is a protein that plays many roles in the body, including sleep regulation, pain management, food intake, and protection against harmful substances. It also affects fat metabolism, glucose intolerance, cell maturation, and is involved in various diseases like diabetes, cancer, and arthritis. It can influence sex organ development and embryonic cell differentiation, and its levels can be used as a diagnostic marker for certain conditions.

Ifidancitinib, a JAK inhibitor, effectively regrows hair in mice with alopecia by tiring out harmful T cells.

Innate immunity genes in hair follicle stem cells might have new roles beyond traditional immune functions.

Foxp3+ Regulatory T Cells are important for immunity and tolerance, affect hair growth and wound healing, and their dysfunction can contribute to obesity-related diseases and other health issues.

The review concludes that innovations in regenerative medicine, tissue engineering, and developmental biology are essential for effective tissue repair and organ transplants.

Different immune cells like platelets, mast cells, neutrophils, macrophages, T cells, B cells, and innate lymphoid cells all play roles in skin wound healing, but more research is needed due to inconsistent results and the complex nature of the immune response.

Regulatory T cells help heal skin and grow hair, and their absence can lead to healing issues and hair loss.

Some antiseizure medications can cause reversible hair loss, with valproate, lamotrigine, and carbamazepine being the most common.

Regulating cell death in hair follicles can help prevent hair loss and promote hair growth.

The nervous system helps control stem cell behavior and immune responses, affecting tissue repair and maintenance.