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The rat model showed early perimenopause with regular cycles and low hormones, and late perimenopause with irregular cycles and higher hormone levels.

The foreword introduces a medical issue discussing male hormonal health, treatments, and the effects of conditions like obesity and aging.

Metformin and thiazolidinediones are similarly effective for PCOS, but metformin is often preferred due to fewer side effects.

Hormone treatments in transsexual individuals reduce hair growth and oil production in male-to-females and increase them in female-to-males.

Baldness caused by male hormones in female-to-male transsexuals doesn't increase the risk of heart disease.

Dietary changes, including weight loss and a balanced diet, are important for managing PCOS, especially in overweight women.

Patients with acanthosis nigricans often have insulin resistance and signs of increased male hormones, but treatment targeting these male hormones is generally ineffective.

Epilepsy and certain epilepsy drugs can lead to reproductive problems in women, but changing medication might improve these issues.

The severity of symptoms in nonclassical congenital adrenal hyperplasia is not determined by CYP21A2 gene variations.

Ovarian Leydig cell tumors are hard to diagnose with just advanced imaging; expert ultrasound and clinical evaluation are essential.

Hormonal therapies are safe and effective for treating acne in female adolescents, with specific treatments for those with endocrine disorders.

High androgen levels in postmenopausal women may suggest an ovarian tumor, and removing it can improve heart and metabolic health.

PCOS is a major cause of infertility in women of childbearing age.

Women with PCOS have more depression and stress due to high androgen levels, not obesity or insulin resistance.

Women with acromegaly often have irregular periods due to hormone imbalances and growth hormone effects.

Acne significantly affects mental health and quality of life, with research suggesting hormonal and genetic factors in its development and emphasizing early treatment to prevent scarring.

Insulin-lowering medications show promise for PCOS symptoms but can't be the main treatment yet due to limited long-term research.

The review found no clear link between vitamin D receptor gene variations and polycystic ovary syndrome.

Hormonal imbalances, often indicating conditions like PCOS, are common in women with hard-to-treat acne, and a treatment approach addressing these imbalances may be needed.

High levels of male hormones and irregular periods best predict how well PCOS patients will respond to metformin treatment.

Benign ovarian tumors can cause excess male hormones and related conditions in postmenopausal women.

Cyproterone acetate treatment is safe and causes mild feminization, which increases with added estrogen.

Measuring reproductive hormones in brown bear hair could help identify their sex and reproductive state, but better collection methods or lab techniques are needed.

The conclusion is that young women with excessive hair growth should be quickly tested for hormonal issues and treated to improve their social well-being.

A woman's masculine symptoms were caused by an ovarian tumor, which improved after surgery.

Finasteride changes hormone levels and certain proteins in rats, but these effects can be reversed after stopping the drug.

People with androgenic alopecia are more likely to have metabolic syndrome than healthy individuals.

Heavily hunted wolves have higher stress and reproductive hormone levels.

Girls with PCOS have higher levels of certain androgens, which are linked to excess hair growth, but these androgens don't help diagnose PCOS.

Removing both ovaries may better treat increased male hormone levels and related symptoms in postmenopausal women when hormone therapy doesn't work.