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The conclusion is that metformin is a first-line treatment for PCOS, particularly for restoring ovulation and increasing pregnancy rates, with other treatments depending on specific symptoms.

The document concludes that ERBB2 mutations are common in extramammary Paget disease and may respond to systemic treatments like cancer immunotherapy.

Hair loss in three Southeast Asian women with kidney failure may be linked to their anemia treatment with erythropoietin.

Hair transplantation is a viable treatment for some types of female hair loss, with careful donor assessment and attention to psychological factors.

Doctors using Google during patient visits can enhance accuracy and outcomes if done transparently and inclusively.

Turing patterns are now recognized as important in developmental biology.

The document's conclusion cannot be provided because the content is not accessible or understandable.

Joint replacement surgery normalized high alkaline phosphatase levels in a patient with severe osteoarthritis.

High-intensity interval training improves certain hormone levels and lipid profiles in women with PCOS.

Certain MC4R gene variants are linked to higher BMI in obese women with PCOS but do not cause PCOS.

Special cell particles from macrophages can help hair grow.

Medroxyprogesterone injections caused hair regrowth in some dogs with alopecia X.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

Understanding how hair follicle stem cells work can help find new ways to prevent hair loss and promote hair growth.

Skin fat plays a key role in immune defense and healing beyond just storing energy.

Hedgehog pathway inhibitors used for skin cancer can cause significant hair loss, which may improve after stopping the medication.

The document concludes that surgery is a preferred treatment for cicatricial alopecia, with the method chosen based on individual factors and may require multiple sessions and careful postoperative care.

Bmpr2 and Acvr2a receptors are crucial for hair retention and color.

Latanoprostene bunod effectively lowers eye pressure and is better tolerated than other glaucoma medications.

Aging in hair follicle stem cells leads to hair graying, thinning, and loss.

Human hair follicle stem cells show signs of low oxygen levels, which may be important for hair growth and preventing baldness.

Eating fewer calories, less sugar and refined carbs, and more low-glycemic and omega-3 rich foods can help manage PCOS symptoms.

Large doses of glucocorticoids are not suitable for general use in treating severe alopecia areata due to inconsistent results and risks.

Different genes and pathways are active in yak skin and hair cells, affecting hair growth and immune responses.

Different sPLA2 enzymes affect immunity, skin and hair health, reproduction, and may be potential targets for therapy.

Hair growth and development are controlled by specific signaling pathways.

The document concludes that proper diagnosis and combined treatments are key for hirsutism management, and weight loss may help overweight patients.

Adult skin cell-based early-stage skin substitutes improve wound healing and hair growth in mice.

Obesity worsens PCOS symptoms, and PCOS may lead to more weight gain; managing both requires a holistic approach that includes mental health.