In this six-year study of a Saudi cohort, oral tofacitinib showed favorable long-term effectiveness for patients with AA, with manageable adverse events requiring regular monitoring.
105 citations
,
January 2004 in “The Journal of Urology” This study found that finasteride significantly improved symptoms in CP/CPPS patients, except for voiding, unlike saw palmetto which showed no long-term benefits.
49 citations
,
June 1998 in “Journal of Endocrinological Investigation” In this study, both cyproterone acetate-estrogen combination (Diane®) and finasteride were effective in reducing hirsutism, but Diane® showed greater long-term efficacy and cost-effectiveness.
8 citations
,
November 2010 in “Facial Plastic Surgery” This review discusses the limitations and techniques of fat transfer for facial rejuvenation, focusing on achieving safe and long-term aesthetic outcomes without providing new clinical results.
5 citations
,
October 2014 in “Scottish medical journal” This case study reports the first known instance of isolated sub-acute cutaneous lupus erythematosus potentially induced by long-term nitrofurantoin therapy, with effective treatment using topical steroids and hydroxychloroquine.
5 citations
,
June 2010 in “Endocrinología y Nutrición” This article discusses PCOS in adolescents and highlights the importance of early diagnosis and treatment to prevent long-term health complications, noting increasing adolescent obesity may worsen symptoms.
2 citations
,
September 2013 in “Journal of Cosmetic Dermatology” This review discusses advancements in managing male androgenetic alopecia, emphasizing long-term restoration techniques like follicular unit grafting combined with medical treatments, and reports no new experimental findings.
March 2026 in “Clinical Cosmetic and Investigational Dermatology” In this case report, a 30-year-old woman with myasthenia gravis developed vitiligo and alopecia universalis during long-term rituximab therapy. Discontinuation of rituximab and initiation of oral baricitinib led to improvement in skin conditions, underscoring potential immune-related skin effects from rituximab.
January 2024 in “Revista de la Asociación Colombiana de Dermatología y Cirugía Dermatológica/Revista de la Asociacion Colombiana de Dermatologia y Cirugia Dermatologica” This case report highlights the successful treatment of alopecia areata universalis with Baricitinib, suggesting potential long-term effectiveness of janus kinase inhibitors for this autoimmune hair loss condition.
January 2024 in “Wiadomości Lekarskie” In this study, researchers at the Laboratory of Regenerative Medicine WUM are exploring the long-term effects of SARS-CoV-19 infection, focusing on stem cell mobilization and engraftment processes, and utilizing advanced diagnostic techniques to develop algorithms for rare disease classification, including amyloidosis.
June 1996 in “Irish Journal of Medical Science (1971 -)” This study found a statistically significant increase in glycosylated hemoglobins among patients with adult-acquired panhypopituitarism undergoing long-term GH replacement therapy, with two developing diabetes requiring treatment.
December 2017 in “Huisarts En Wetenschap” Finasteride helps hair growth in early male baldness, but more long-term research needed.
3 citations
,
May 2024 in “Cureus” This study found that LAHR significantly improves the quality of life in the short term for women with PCOS, but underscores a need for further research to develop long-term treatment strategies.
April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that using a commercially available IPL home-use device led to significant hair reduction and demonstrated long-term efficacy in maintaining hair reduction one year after treatment.
75 citations
,
November 2016 in “Medicines” This review discusses the properties and therapeutic potentials of beta-sitosterol, highlighting a need for more detailed studies on its mechanisms and long-term effects in humans; it reports no new results.
61 citations
,
January 2015 in “Indian Journal of Plastic Surgery” This study found that platelet-rich plasma may have a role in treating chronic alopecia areata, but more long-term follow-up studies are needed to confirm its effectiveness and success rate.
38 citations
,
January 2014 in “International Journal of Endocrinology” This review highlights that children with adrenal disorders may experience neurological and psychiatric symptoms, with potential long-term cognitive and behavioral effects from excess glucocorticoids.
35 citations
,
May 2012 in “Expert Opinion on Pharmacotherapy” This review summarizes current and emerging treatments for common hair loss conditions, highlighting good evidence for androgenetic alopecia but noting the lack of long-term data for alopecia areata and cicatricial alopecias.
1 citations
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August 2023 in “Frontiers in immunology” This review highlights the potential of TCM medicinal foods for managing post-COVID disorders and suggests they could provide a safe and efficient long-term therapy due to their milder nature.
September 2025 in “Drug Design Development and Therapy” This study suggests that while platelet-rich products show promise in treating dermatological conditions like chronic wounds and skin aging, there is still a need for standardized methodologies and extensive trials to confirm their long-term clinical benefits.
166 citations
,
October 2018 in “Endocrine Reviews” This review discusses the effects of hormonal treatments on the physical and mental health of transgender individuals, reporting significant reductions in mental health issues following treatment, but calls for more research on long-term and nonbinary outcomes.
5 citations
,
May 2008 in “Pediatric Diabetes” Low-glycemic index diets are beneficial for weight loss and satiety, but more research is needed on long-term effects and individualized approaches are recommended.
January 2020 in “Elsevier eBooks” This chapter provides an overview of phytochemicals with properties to combat alopecia and discusses the potential of flavonoids, found in several herbs, as a safer alternative to synthetic hair loss treatments due to their long-term skin compatibility.
52 citations
,
February 2006 in “Current pharmaceutical design” This review discusses the use of 5α-reductase inhibitors in treating benign prostatic hyperplasia, highlighting their long-term effectiveness and benefits when combined with α1-adrenergic antagonists; it reports no new clinical results.
104 citations
,
August 2008 in “Clinics in Dermatology” This review discusses current treatment challenges and strategies for managing psoriasis in the scalp, nails, and intertriginous areas, emphasizing the need for effective and well-tolerated long-term options, but reports no new clinical results.
71 citations
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March 2009 in “Seminars in cutaneous medicine and surgery” This review discusses evidence for alopecia areata treatments, highlighting their ability to stimulate hair growth but noting limited data on long-term efficacy and impact on quality of life.
56 citations
,
January 2021 in “Clinical and Experimental Medicine” This review highlights the challenges in treating alopecia areata, noting that current therapies often lead to relapse and have uncertain long-term effectiveness; it also points to potential future treatments such as JAK-STAT inhibitors and PRP.
39 citations
,
April 2024 in “Frontiers in Endocrinology” This study reviews the causes, mechanisms, and treatments for thin endometrium, highlighting multiple contributing factors such as hormonal influences, long-term oral contraceptive use, and uterine inflammation, while noting unclear mechanisms in promising therapeutic strategies like pharmacological treatments and regenerative medicine approaches.
35 citations
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June 2018 in “Urology” This study of FAERS data suggests that finasteride, particularly at the 1 mg dosage, is associated with a wide range of adverse effects not previously established in long-term studies, especially among younger men.
34 citations
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April 2009 in “Expert Opinion on Pharmacotherapy” This review discusses evidence-based treatments for common hair loss forms, noting robust support for androgenetic alopecia therapies but limited long-term data and fewer high-quality studies for alopecia areata and cicatricial alopecias.