4 citations
,
January 1991 in “Journal of dermatological treatment” This study found that GnRH-A treatment significantly reduced hirsuties scores in women with mild idiopathic hirsuties but did not affect hair growth rate or diameter.
October 2021 in “Research Society and Development” This review discusses potential drug interactions between herbal medicines and oral contraceptives, reporting no new research results but highlighting the risk these interactions pose to contraceptive effectiveness.
9 citations
,
June 2020 in “Trials” This study aims to conduct the first double-blind randomized trial comparing spironolactone and doxycycline for female acne treatment, with the goal of establishing spironolactone as a potentially superior alternative, especially given concerns about antibiotic resistance.
January 2026 in “Journal of Education Health and Sport” This review assesses whether using letrozole alongside physical activity and nutrition is clinically beneficial for enhancing ovulation outcomes in women with PCOS-related infertility, but it doesn't report specific results from the evaluation.
57 citations
,
January 1995 in “The American journal of medicine” This study discusses the use of oral contraceptives as a treatment for hyperandrogenism, showing improvement in hirsutism and acne for many women and possibly providing metabolic benefits with certain formulations.
4 citations
,
January 2018 in “JBRA assisted reproduction” This study found that orlistat significantly reduced weight and total testosterone levels in Iranian women with polycystic ovary syndrome after 12 weeks of treatment.
24 citations
,
May 1995 in “Journal of Adolescent Health” This study of Black and Hispanic inner-city teens found that Norplant retention rates were 71% at one year and 62% at two years, with a history of induced abortion predicting higher continuation.
6 citations
,
February 2009 in “Veterinární Medicína” This study found that deslorelin implants can effectively reduce estradiol levels and support hair regrowth in neutered ferrets with hyperoestrogenism caused by nodular hyperplasia of the adrenocortex.
41 citations
,
February 1970 in “Archives of Dermatology” This review discusses various cutaneous side effects potentially linked to oral contraceptive use but provides no new clinical results, emphasizing the need for more evidence in certain associations.
August 2026 in “International Journal of Dermatology” This article discusses the availability of data from TriNetX for research purposes and reports no new findings.
43 citations
,
July 2017 in “International journal of pharmaceutics” This study found that anionic HSES achieved high complexation efficiencies with various steroids, significantly enhancing their solubility, while specific β-cyclodextrin thioethers showed selective binding to testosterone and estradiol.
25 citations
,
September 1977 in “Journal of Toxicology and Environmental Health” This study in female beagle dogs found that long-term exposure to oral contraceptive steroids resulted in significant reproductive and mammary gland changes, with the relevance to human tumor risk remaining uncertain.
This research review found that spironolactone can significantly improve acne severity more effectively than a placebo, with 73.3% of patients reporting satisfaction despite a 26.7% rate of adverse events among the 1,548 participants studied.
This abstract details known indications, categories, and potential reactions for various drugs, including anorexiants, estrogens, NSAID analgesics, cardiac glycosides, and migraine preventives, without reporting new clinical results.
1 citations
,
June 1987 in “British journal of dermatology/British journal of dermatology, Supplement” This study found that despite a high incidence of side effects, patients generally tolerated spironolactone while benefiting from its treatment effects for acne and hirsutism.
3 citations
,
December 1997 in “Pediatric Clinics of North America” This article reviews adolescent sexual behavior and emphasizes the importance of hormonal contraception for sexually active teenagers, suggesting that health care providers play a crucial role in addressing their reproductive needs.
1 citations
,
October 2006 in “Journal of Family Planning and Reproductive Health Care” This case report describes a woman who developed a 5 cm patch of scalp hair loss four months after receiving an Implanon contraceptive implant, with no previous history of hair loss or scalp issues.
2 citations
,
April 2019 in “Медицинский совет” This article reviews the problem of acne and hirsutism in women, highlighting the effectiveness of combined oral contraceptives containing drospirenone and levomefolate calcium in managing these conditions and polycystic ovary syndrome, but no new clinical results are reported.
61 citations
,
January 2017 in “Human Reproduction Open” This review discusses hormone replacement therapy for women with premature ovarian insufficiency, strongly recommending it for symptom relief and bone protection, but notes a lack of evidence on optimal types and doses.
April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that the natural estrogen Estetrol (E4) may promote hair follicle growth and prevent miniaturization, suggesting its potential as a treatment for hair loss disorders.
46 citations
,
May 2009 in “Maturitas” This study found that taking a daily oral dose of 50mg DHEA for one year had no significant impact on blood lipids, insulin sensitivity, or the endometrium in postmenopausal women with low libido.
120 citations
,
October 2007 in “Clinical Interventions in Aging” This review discusses the effects of estrogens on skin aging and highlights the potential benefits of estrogen replacement therapy and selective estrogen receptor modulators for improving skin health in postmenopausal women, but reports no new clinical findings.
8 citations
,
March 2008 in “Deutsche medizinische Wochenschrift/Deutsche Medizinische Wochenschrift” This case study found that in a male-to-female transgender individual, long-term cyproterone use led to decreased bone mass, which improved with additional oestradiol treatment, highlighting the anabolic role of oestrogens on bone health.
7 citations
,
August 2010 in “Medicinal Chemistry Research” This study found that some synthesized 17-oximino-5-androsten-3β-yl esters demonstrated stronger cytotoxicity and antiandrogenic activity against prostate cancer cells than finasteride.
January 2002 in “Chinese Journal of Pharmaceuticals” This study reports the preparation of a key intermediate for finasteride and epristeride with a 69% overall yield from pregnenolone acetate.
15 citations
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April 2008 in “Steroids” This study found that pregnane derivatives with higher lipophilicity, like compound 9d, had stronger androgen receptor binding and greater antiandrogenic effects in rats, correlating relative binding affinity with log P values.
In this study, metformin, pioglitazone, and ethinylestradiol cyproterone all improved various clinical features and quality of life in Pakistani women with PCOS, though no drug significantly reduced hirsutism.
1 citations
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June 2019 in “Current Developments in Nutrition” This study found that after 12 weeks of taking 10 mg of S-equol daily, over 90% of participating perimenopausal and menopausal women reported improvements in symptoms like hot flashes, night sweats, and sleep disturbances.
April 2025 in “Pharmacy Practice” This study assessed the impact of hormonal contraceptives on liver function in 46 women aged 25-45 and found that contraceptive users, particularly those using combined oral contraceptives, had significantly higher liver enzyme levels compared to non-users, suggesting potential adverse effects that warrant further investigation.
30 citations
,
January 1998 in “Dermatology” This review discusses hormonal influences and treatment considerations in female acne, particularly highlighting the role of androgens in persistent or resistant cases, and reports no new clinical findings.