Effects of Orlistat on Serum Androgen Levels Among Iranian Obese Women With Polycystic Ovarian Syndrome

January 2018 in “ JBRA assisted reproduction ”

Saghar Salehpour, Sedighe Hosseini, Leila Nazari, Nasrin Saharkhiz, Shahrzad Zademodarres

orlistat serum androgen levels testosterone polycystic ovary syndrome PCOS luteinizing hormone LH Alli Xenical

TLDR Orlistat helped reduce weight and testosterone in obese women with PCOS but did not significantly affect other androgens or cholesterol levels.

In 2018, a study was conducted on 32 Iranian women with polycystic ovary syndrome (PCOS) to investigate the effects of Orlistat, a weight-loss drug. The study found that Orlistat significantly reduced weight, body mass index (BMI), and serum testosterone levels in these women. However, it did not significantly reduce other androgen levels, serum cholesterol, triglyceride, and low-density lipoprotein (LDL) levels, or fasting insulin and luteinizing hormone (LH) levels. The study suggested that longer treatment with Orlistat might be needed to see a significant reduction in serum LH level. The study had a relatively low number of participants, which might have affected the significance of some results.

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Research cited in this study

4 / 4 results

research Androgen Receptor Gene Polymorphism and Polycystic Ovary Syndrome

45 citations, November 2012

The conclusion is that androgen receptor gene polymorphism might be a marker for polycystic ovary syndrome, but more research is needed.

research The Androgen Excess and PCOS Society Criteria for the Polycystic Ovary Syndrome: The Complete Task Force Report

1540 citations, October 2008 in “Fertility and Sterility”

The report concludes that PCOS is mainly a condition of excess male hormones and its definition may change as new information is discovered.

research Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome (PCOS)

4025 citations, December 2003 in “Human Reproduction”

The 2003 consensus updated PCOS diagnosis criteria and linked PCOS to higher risks of diabetes and heart problems, recommending lifestyle changes to lower these risks.

research Prevalence of Polycystic Ovary Syndrome in Unselected Black and White Women of the Southeastern United States: A Prospective Study

633 citations, September 1998 in “The Journal of Clinical Endocrinology and Metabolism”

PCOS affects a similar percentage of Black and White women in the Southeastern United States.

Related Research

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research Effects of Orlistat on Serum Androgen Levels Among Iranian Obese Women With Polycystic Ovarian Syndrome

4 citations, January 2018 in “JBRA assisted reproduction”

Orlistat helped reduce weight and testosterone in obese women with PCOS but did not significantly affect other androgens or cholesterol levels.