Letrozole-Assisted Ovulation Induction Combined With Lifestyle Modification in Women With PCOS: A Review

This review evaluates the clinical appropriateness of using letrozole, an aromatase inhibitor, alongside lifestyle modifications such as physical activity and nutrition to enhance ovulation outcomes in women with polycystic ovary syndrome (PCOS) experiencing infertility. Letrozole, initially developed for breast cancer treatment, is highlighted as a promising first-line pharmacological agent for ovulation induction in PCOS patients. The review involves a comprehensive analysis of research articles sourced from PubMed and Google Scholar, focusing on the combined effects of letrozole and lifestyle changes on improving fertility in women with PCOS.