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Sonidegib and vismodegib are similarly effective for advanced basal cell carcinoma, but sonidegib might have a slightly better safety profile.

The Polish medical societies have redefined metabolic syndrome and recommend lifestyle changes, certain medications, and possibly bariatric surgery for treatment. They also discuss managing related health conditions.

Some medications caused temporary health issues that improved after stopping the drugs, but two patients died from liver problems linked to carbamazepine.

Lepidium sativum seed extracts helped reduce inflammation and improve insulin response in obese rats on a high-fat diet.

Certain genetic variations in OCT1 may improve insulin sensitivity with metformin in women with PCOS.

Wounds can regenerate hair in young mice, but this ability declines with age, offering insights for improving tissue regeneration in the elderly.

Some acne medications have side effects; doctors should educate patients and may not need to do frequent lab tests for all.

5α-reductase inhibitors can interfere with doping tests by masking banned substances.

Insulin resistance may contribute to hair loss in people with androgenic alopecia.

CHOP chemotherapy causes many side effects but is generally well tolerated.

Methotrexate treats various disorders by inhibiting DNA synthesis, but careful monitoring is needed to avoid toxicity and manage side effects.

Transplant success has improved with better immunosuppressive drugs and donor matching.

Isotretinoin effectively treats severe acne and similar conditions, but has common, mostly reversible side effects, requiring careful patient monitoring.

The document concludes that better biomarkers are needed to detect long-term oral testosterone use in athletes.

Finasteride is a safe, effective treatment for hirsutism with fewer side effects.

Oxidative stress is a key factor in the development of Polycystic Ovary Syndrome, and weight management can improve symptoms.

Women with PCOS have more severe liver disease.

Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.

Certain metabolites are lower in women with PCOS and could be potential markers for the condition.

Most patients with Porphyria Cutanea Tarda had skin blisters and were often affected by hepatitis C and alcohol abuse, with differences between familial and sporadic cases.

Cyproterone acetate treatment is safe and causes mild feminization, which increases with added estrogen.

Hair loss linked to metabolic issues and insulin resistance; early assessment may reduce future health risks.

Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

Insulin resistance is linked to high male hormone levels in women, often seen in those with PCOS.

Systemic retinoids are effective for psoriasis but have side effects; benefits may outweigh risks, especially when reducing cancer risks from other treatments.

Long-term use of finasteride and dutasteride can cause serious health issues like diabetes and liver problems.

Oral bicalutamide is safe and effective for female hair loss.

Chromium supplements don't help with weight loss or improve hormone and metabolism issues in people with polycystic ovary syndrome.

Testosterone therapy seems safe for short-term use in postmenopausal women with low sexual desire, but more research on long-term effects is needed.

Some men with early hair loss may have a male version of PCOS, affecting hormones and increasing health risks.