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Methotrexate treats various disorders by inhibiting DNA synthesis, but careful monitoring is needed to avoid toxicity and manage side effects.

Transplant success has improved with better immunosuppressive drugs and donor matching.

Isotretinoin effectively treats severe acne and similar conditions, but has common, mostly reversible side effects, requiring careful patient monitoring.

The document concludes that better biomarkers are needed to detect long-term oral testosterone use in athletes.

Finasteride is a safe, effective treatment for hirsutism with fewer side effects.

Oxidative stress is a key factor in the development of Polycystic Ovary Syndrome, and weight management can improve symptoms.

Women with PCOS have more severe liver disease.

Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.

Certain metabolites are lower in women with PCOS and could be potential markers for the condition.

Most patients with Porphyria Cutanea Tarda had skin blisters and were often affected by hepatitis C and alcohol abuse, with differences between familial and sporadic cases.

Cyproterone acetate treatment is safe and causes mild feminization, which increases with added estrogen.

Hair loss linked to metabolic issues and insulin resistance; early assessment may reduce future health risks.

Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

Insulin resistance is linked to high male hormone levels in women, often seen in those with PCOS.

Systemic retinoids are effective for psoriasis but have side effects; benefits may outweigh risks, especially when reducing cancer risks from other treatments.

Long-term use of finasteride and dutasteride can cause serious health issues like diabetes and liver problems.

Oral bicalutamide is safe and effective for female hair loss.

Chromium supplements don't help with weight loss or improve hormone and metabolism issues in people with polycystic ovary syndrome.

Testosterone therapy seems safe for short-term use in postmenopausal women with low sexual desire, but more research on long-term effects is needed.

Some men with early hair loss may have a male version of PCOS, affecting hormones and increasing health risks.

New signs like changes in blood markers, physical symptoms, and behavioral shifts may help detect hidden steroid use in athletes.

The conclusion is that managing cholesterol is important for women, especially during pregnancy, breastfeeding, and with PCOS, and involves regular screening and careful treatment choices.

Epidermal stem cells have potential for personalized regenerative medicine but need careful handling to avoid cancer.

Bicalutamide may be a promising alternative treatment for female pattern hair loss.

A specific group of slow-growing stem cells marked by Thy1 is crucial for skin maintenance and healing in mice.

Blood removal and birth control pills both helped with hormone levels in women with PCOS, but birth control was better for regular periods and blood removal had fewer side effects.

The review suggests renaming two herbs to avoid confusion and recommends more research for safe use.

Skin and hair changes in horses can indicate serious diseases, and recognizing these signs is important for treatment and management.

Skin tags in obese individuals may indicate higher cardiovascular risk.

Chromium salts may help with insulin sensitivity in PCOS, but more research is needed to confirm their overall effectiveness and safety.