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Stem cell-derived conditioned medium shows promise for treating various medical conditions but requires standardized production and further validation.

TRPA1 is crucial for mechanical sensitivity in skin sensory neurons.

Apple polyphenol, especially oligomeric procyanidins, can reduce fat absorption and lower blood fat levels.

The Endocrine Society advised against routine testosterone therapy for women, citing a need for more research on long-term safety and a clear definition of androgen deficiency.

Manage vitiligo with treatments, address emotions, and use camouflage techniques.

Platelet-rich plasma can potentially promote hair growth by stimulating cell growth and increasing certain proteins.

The Rotterdam Study aims to understand disease causes in the elderly and has found new risk factors and genetic influences on various conditions.

Zinc oxide nanoparticles in sunscreen do not penetrate deep into the skin.

Medium-sized particles penetrate hair follicles better than smaller or larger ones, which could improve delivery of skin treatments.

Niosomes are a promising, stable, and cost-effective drug delivery system with potential for improved targeting and safety.

Mutations in the SRD5A3 gene cause a new type of glycosylation disorder by blocking the production of a molecule necessary for protein glycosylation.

Spironolactone treatment increases the amount of testosterone available in the body.

Melatonin in the skin helps protect against damage from stress and UV rays, and could be used to treat certain skin conditions.

The guidelines advise against using testosterone and DHEA in women for most conditions due to safety and effectiveness concerns, but suggest considering testosterone for postmenopausal women with low sexual desire.

Human skin can make serotonin and melatonin.

The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

Dermoscopy is a useful tool for identifying features of skin conditions, but more research is needed to define its role in dermatology.

Hair loss and aging are caused by the breakdown of a key protein in hair stem cells.

The timing of when the gene Bmal1 is active affects aging and survival, with its absence during development, not adulthood, leading to premature aging.

Cells from balding scalps have more androgen receptors than cells from non-balding scalps.

Melatonin is important for skin health and protection, and can be made by the skin or applied to it.

Biomaterials with MSC-derived substances could improve tissue repair and have advantages over direct cell therapy.

The Rotterdam Study aims to understand various diseases in older adults.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

The skin is a complex barrier for drug penetration, but understanding its structure and interactions can improve drug delivery methods.

Noggin is necessary to start the hair growth phase in skin after birth.

Finasteride effectively treats BPH, but needs more trials to understand potential.

Hair color production in mice is closely linked to the hair growth phase and may also influence hair growth itself.

The Multi-Organ-Chip improves the growth and quality of skin and hair in the lab, potentially replacing animal testing.

Laser hair removal is the most requested cosmetic procedure and has become a scientifically-based treatment suitable for all skin types.