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PLD is an effective and safer alternative for treating breast cancer.

C60 fullerenes can alter protein function and may help develop new disease inhibitors.

Fullerenes show potential in skin care but need more safety research.

The sebaceous gland has more roles than just producing sebum and contributing to acne, and new research could lead to better skin disease treatments.

The human hair follicle can store topical compounds and be targeted for drug delivery with minimal side effects.

Antiandrogens affect androgen-dependent body functions and are used for various medical conditions, with some risks like fetus feminization, but new forms like 17α-propylmesterolone show promise for acne without systemic effects.

Nanoparticles can improve skin treatments by better targeting hair follicles, but more research is needed for advancement.

Eating a high-glycemic diet may worsen acne by increasing certain protein levels and expressions in the skin.

Using nanostructured lipid carriers to deliver spironolactone could improve treatment for hair loss.

Cholesterol sulfate buildup due to a genetic mutation disrupts the skin barrier, leading to the scaling skin seen in X-linked ichthyosis.

Liposomes better deliver minoxidil for hair loss treatment than niosomes.

The document concludes that understanding sulfation biology is crucial for creating treatments due to its importance in biological functions and disease.

Hormones, especially androgens, play a key role in acne, which can be a symptom of systemic diseases like PCOS and may require targeted treatment.

Chemotherapy often causes skin, nail, and hair side effects, significantly impacting quality of life.

Finasteride effectively reduces hair growth in women with idiopathic hirsutism, but requires careful contraception during treatment.

Triparanol therapy can cause hair loss and skin dryness without inflammation or damage to hair follicles or skin structures.

Niosomes are promising for skin drug delivery, offering benefits like improved drug penetration and stability.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

Minoxidil and finasteride treat hair loss; more research needed for other options.

Long-term testosterone therapy can cause hormone suppression, affect prostate and heart health, and alter physical characteristics, but does not increase prostate cancer risk and needs more research for full risk assessment.

Testosterone treatment effectively causes male physical development in transgender male adolescents but may lead to side effects like acne, higher BMI and blood pressure, lower good cholesterol, and decreased bone density.

The document explains how the male reproductive system works, its role in making testosterone, and how conditions like obesity can disrupt it, leading to low testosterone and fertility issues.

PCOS affects women's health by increasing the risk of diabetes, heart disease, and reproductive issues.

Acne is caused by genetics, diet, hormones, and bacteria, with treatments not yet curative.

Nonionic liposomes are the best for delivering genes to skin cells.

Anti-acne medications may work by reducing the activity of a protein involved in acne development.

PEGL-DOX causes Hand-Foot Syndrome due to skin reactions from prolonged circulation and ROS generation.

Some drugs can cause hair loss, and stopping these drugs often leads to hair regrowth.

Sebaceous glands in the skin play a key role in absorbing the antiandrogen drug RU 58841, especially when it's encapsulated in liposomes.

Cationic polymers improved liposome stability and increased skin absorption of aciclovir and minoxidil.