195 citations
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January 2008 in “Photochemistry and Photobiology” This review discusses the effects of visible light on human skin, highlighting its role in pigmentation, thermal damage, and the treatment of several skin conditions, while noting limited sunscreen protection against it; no new clinical results are reported.
46 citations
,
September 2010 in “Southern Medical Journal” This review discusses low-level light therapy for androgenetic alopecia and female pattern hair loss, noting minimal clinical evidence on its efficacy and the need for more controlled studies.
43 citations
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September 2017 in “Lasers in Surgery and Medicine” This study found that LED light irradiation induced proliferation and migration of human outer root sheath cells, potentially through the stimulation of the Wnt/β-catenin and ERK signaling pathways.
33 citations
,
January 2021 in “Aesthetic Surgery Journal” This review suggested that low-level light therapy using red/near-infrared light could be a safe and effective treatment for various skin and hair conditions, though more robust trials are needed to solidify its clinical utility.
16 citations
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November 2016 in “Journal of Cosmetic and Laser Therapy” This review highlights that laser and light treatments could serve as safe and effective alternatives to current therapies for alopecia areata, with the excimer laser showing positive results, though further randomized controlled trials are necessary to establish optimal treatment protocols.
7 citations
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March 2016 in “Journal of Cosmetic and Laser Therapy” This review suggests that paradoxical hair growth after light-based treatments is unlikely due to the devices themselves; instead, it may be linked to other factors such as inflammation in individuals with certain conditions.
5 citations
,
October 2020 in “Lasers in Medical Science” This study found that combination therapy with LLLT and 5% minoxidil improved hair diameter and density more effectively than each treatment alone in women with female pattern hair loss.
January 2026 in “Forum Dermatologicum” This review concluded that LED-based photobiomodulation is generally safe and effective for certain dermatologic conditions, though consumer devices often show less efficacy compared to professional systems.
This study concluded that adding a topical agent to intense pulsed light therapy significantly improved hair reduction and patient satisfaction in Pakistani women with idiopathic facial hirsutism compared to light therapy alone, without increasing adverse effects.
July 2002 in “Dermatologic Surgery” This study found that temporary or permanent leukotrichia may occur after intense pulsed light therapy for hair removal, likely due to differing thermal effects on melanocytes and hair follicle cells.
5 citations
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March 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that Piezo2 channels are primarily located on sensory axon membranes in mechanosensory end organs, supporting a model where mechanical stimuli activate Aβ RA-LTMR neurons via axon protrusions.
1 citations
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February 2025 in “Frontiers in Endocrinology” In this study, researchers observed that dietary vitamin D intake and light exposure play a crucial role in vitamin D metabolism in mice, suggesting similar importance for human health in maintaining optimal vitamin D levels.
January 2019 in “Durham e-Theses (Durham University)” This study utilized advanced imaging techniques to quantify hair damage and dye uptake dynamics, revealing that compound penetration in hair is influenced by molecule size and lipophilicity.
August 2018 in “Journal of Investigative Dermatology” This study found that combining optical clearing methods with light-sheet fluorescence microscopy allows detailed 3D visualization of normal and pathological human skin biopsies, revealing differences in epidermal thickness and volume.
24 citations
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March 2015 in “Dermatologic Surgery” This review discusses the modest efficacy of home-use laser and light devices for conditions like hair removal and acne, noting limited evidence and a lack of robust trials.
January 2003 in “Research Portal (King's College London)” This study employed a laser-based method to analyze how light reflection patterns vary on human hair fibers, revealing changes related to hair color and the tilt of the cuticle cells.
24 citations
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January 2011 in “International Journal of Trichology” This review highlights the light microscopic features of various infectious and non-infectious hair conditions and reports no new clinical results.
11 citations
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February 2020 in “Dermatology and therapy” This study reported that four patients with lichen planopilaris showed dramatic improvement, including symptom reduction and hair regrowth, after treatment with low-level light therapy.
6 citations
,
September 2018 in “Journal of Dermatological Treatment” This review examines the FDA's 510(k) approval process for low-level laser therapy devices used in treating androgenetic alopecia and reports no new clinical findings.
3 citations
,
October 1979 in “Laboratory animals” This study found that phenylbutazone and fluocinolone acetonide have similar anti-redness effects in both haired and hairless animals, making hairless rats a potential alternative for testing without needing depilation.
January 2019 in “Global Dermatology” This review discusses the genetic disorder, monilethrix, characterized by fragile, brittle hair and its inheritance patterns, and reports no new clinical results.
March 2026 in “Quality in Sport” This review evaluates photobiomodulation's diverse clinical uses in sports and medicine, reporting physiological modulation and potential therapeutic benefits, but emphasizes the importance of precise dosimetry for success.
67 citations
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October 1997 in “Dermatologic Surgery” This study found that the EpiLight Hair Removal System achieved approximately 60% hair removal after 12 weeks following a single treatment, indicating effectiveness and safety for long-term hair reduction.
33 citations
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January 2017 in “Annals of Dermatology” This study suggests that LED light may promote the proliferation of human dermal papilla cells through the activation of specific signaling pathways.
31 citations
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June 2018 in “Dermatologic Surgery” In this randomized, double-blind trial, researchers observed that low-level laser therapy led to significantly greater hair regrowth on treated areas compared to a sham treatment in patients with androgenetic alopecia over 24 weeks, suggesting it as a potentially effective and safe option.
17 citations
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December 2015 in “International Journal of Cosmetic Science” This review discusses the effectiveness of non-thermal, non-ablative devices like light-emitting diodes in treating various skin and hair conditions but reports no new clinical findings.
8 citations
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July 2020 in “Medicine” In this study, low-level light therapy using a new helmet-type device significantly increased hair density and thickness in patients with androgenetic alopecia, showing no adverse events or side effects, suggesting it may be a safe and effective treatment option for both sexes.
6 citations
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November 2018 in “Photodiagnosis and Photodynamic Therapy” This study found that using a wearable low-level light therapy device for photodynamic therapy significantly reduced actinic keratosis lesions and improved quality of life in patients with AK of the scalp.
6 citations
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June 2013 in “British Journal of Dermatology” This study found that intense pulsed light treatment primarily targets pigmented structures in hair follicles and may damage dermal papilla cells at high energy levels, but stem cells are mostly spared.
August 2025 in “Aesthetic Cosmetology and Medicine” In this article, researchers explored how blue light exposure affects the scalp and hair follicles, highlighting oxidative stress and hair growth disruptions, while emphasizing the importance of protective strategies like antioxidants and limiting light exposure.