Common Genetic Hair Shaft Abnormalities May Be Visualized by Light and Electron Microscope

January 2019 in “ Global Dermatology ”

Saad R Abed

genetic hair shaft abnormalities light microscope electron microscope atopy cornification monilethrix autosomal dominant disorder K83 Desmoglein bamboo defects

The document discussed genetic hair shaft abnormalities that could be observed using light and electron microscopes. It highlighted conditions such as atopy, where hair breakage occurred due to defective cornification, and monilethrix, an autosomal dominant disorder characterized by fragile, brittle hair with elliptical nodes and constrictions. While scalp hair in adults tended to improve, bamboo defects in eyebrow and body hair could persist. Mutations in genes encoding K83 and Desmoglein were identified, with the scalp usually being the primary area affected, though more extensive cases could involve eyebrows, eyelashes, and nails.

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