Low-Level Light-Assisted Photodynamic Therapy Using a Wearable Cap-Like Device for the Treatment of Actinic Keratosis of the Scalp

    November 2018 in “ Photodiagnosis and Photodynamic Therapy ”
    Pablo Fonda‐Pascual, A. Alegre-Sánchez, Antonio Harto-Castaño, Óscar M. Moreno‐Arrones, B. Pérez‐García, María Luisa González-Morales, Cristina Pindado‐­Ortega, Yolanda Gilaberte, José Aguilera, Pedro Jaén‐Olasolo, M. Fernández‐Guarino
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    TLDR A wearable cap-like device using light therapy reduced scalp skin lesions by 71% and was painless.
    In a pilot study from 2017 involving 27 male patients with actinic keratosis (AK) of the scalp, a wearable cap-like device delivering low-level light therapy (LLLT) was used immediately after applying methyl-aminolevulinate (MAL) cream. The study found a 71% reduction in AK lesions and a decrease in the AK quality of life score from 5.6 to 4.4 two months post-treatment. Histological and immunohistochemical analyses supported these findings, showing improvements in skin condition. The treatment was painless and well-tolerated. Despite the promising results, the study's limitations included a small sample size and the absence of a control group, suggesting the need for further research.
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