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The vitamin D receptor is crucial for bone health and affects various body systems, with mutations potentially leading to disease.

Human skin makes sexual hormones that affect hair growth, skin health, and healing; too much can cause acne and hair loss, while treatments can manage these conditions.

The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.

Vitamin D and its receptor regulate skin functions like cell growth, immunity, hair cycle, and tumor prevention.

Estrogen therapy can reduce skin aging but has cancer risks.

Targeting the IL-23/IL-17 pathway effectively treats several inflammatory skin diseases.

Eating less sugar, milk, and saturated fats and more vegetables and fish may help treat and prevent acne.

New targets for making and using brain-synthesized steroids could lead to better treatments for brain disorders and alcoholism.

Male pattern baldness involves hormones and cell signals affecting hair growth.

Male hormones like testosterone may make COVID-19 worse, and testing for sensitivity to these hormones could help predict how severe a patient's symptoms might be. Treatments that reduce these hormones are being explored.

Estrogens help reduce skin aging, and SERMs might offer similar benefits without the risks of hormone therapy.

FGF signaling is a promising target for developing treatments for wounds, metabolic diseases, and cancer.

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

The Wnt/β-catenin pathway helps tissue regeneration but can also cause fibrosis, and drugs that inhibit this pathway may aid in healing skin and heart tissues.

5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.

Mice without the vitamin D receptor gene lose hair due to disrupted hair follicle cycles.

Insulin resistance may contribute to various skin diseases and treating it could improve skin health and prevent more serious conditions.

Oestrogens help maintain healthy skin, heal wounds, and may protect against skin aging and cancer.

Androgen receptors are key for development and health, affecting conditions like prostate cancer and male pattern baldness.

Kennedy's disease leads to muscle weakness and sensory issues, has no cure but manageable symptoms, and future treatments look promising.

Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.

The drug enzalutamide may reduce the ability of the virus causing COVID-19 to enter lung cells.

Wnt signaling is important for development and cell regulation but can cause diseases like cancer when not working properly.

Eph/ephrin signaling is important for skin cell behavior and could be targeted to treat skin diseases.

Most Hairless gene mutations reduce its ability to work with the Vitamin D Receptor, which might explain a certain type of hair loss.

Most pregnant women experience skin changes like darkening and stretch marks, and some may have skin conditions that usually get better after giving birth.

Androgens may influence T cells, contributing to higher autoimmune liver disease risk in women.

Stress activates a special function of the Vitamin D receptor with the help of c-Jun, which can also prevent cell death.

Scutellaria baicalensis extract and baicalin may help prevent hair loss.

Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.