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TRPA1 is crucial for mechanical sensitivity in skin sensory neurons.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

The conclusion is that proper signaling is crucial for hair growth and development, and errors can lead to cancer or hair loss.

Biomaterials with MSC-derived substances could improve tissue repair and have advantages over direct cell therapy.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Targeted cancer therapies often cause serious skin problems that need careful management.

Cancer treatments targeting specific cells and the immune system can cause skin, mouth, hair, and nail problems, affecting patients' quality of life and treatment adherence.

Capsaicin, found in chili peppers, can slow down hair growth by affecting skin cells and hair follicles.

Fibromodulin might help reduce scarring if increased in adult wounds like in fetal skin that heals without scars.

Blocking COX, especially COX-2, in the skin can reduce inflammation and pain and may help prevent skin cancer.

TGF-β is crucial for controlling stem cell behavior and changes in its signaling can lead to diseases like cancer.

Nanoparticles improve drug delivery through the skin but more research is needed on their long-term effects and skin penetration challenges.

The dermal papilla is crucial for hair growth and health, and understanding it could lead to new hair loss treatments.

Targeting the IL-23/IL-17 pathway effectively treats several inflammatory skin diseases.

Finasteride treats enlarged prostate and hair loss, but may cause side effects in some patients.

The drug IPI-926 is safe at 160 mg daily and may help treat certain tumors, especially basal cell carcinoma.

Fat-derived stem cells show promise for skin repair and reducing aging signs but need more research for consistent results.

TGF-β signaling is crucial for stem cell maintenance, differentiation, and has implications for cancer treatment.

Normal skin cell renewal doesn't need RAR signaling, but vitamin A-related skin thickening does.

Janus kinase inhibitors are promising treatments for autoimmune skin diseases like eczema and psoriasis.

Targeting androgen receptors could be a promising way to treat skin disorders with fewer side effects.

Dexamethasone speeds up hair loss in mice, while cyclosporin A slows it down.

New targets for making and using brain-synthesized steroids could lead to better treatments for brain disorders and alcoholism.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

Macrophages help regrow hair by activating stem cells using AKT/β-catenin and TNF.

Too much Smad7 can cause serious changes in skin tissues, including problems with hair growth, thymus shrinkage, and eye development issues.

Giving a special protein to dogs with a certain genetic disease improved their symptoms but didn't help with hair growth.

Fetal wound healing changes with development, affecting inflammation and collagen, which may influence scarring.

Lampreys have a functional vitamin D receptor that may help detoxify harmful substances.

Hair follicles are hormone-sensitive and involved in growth and other functions, with potential for new treatments, but more research is needed.