97 citations
,
November 1986 in “Journal of Steroid Biochemistry” This review discusses the pharmacological properties and clinical applications of cyproterone acetate and similar antiandrogens, noting previous failures in local applications due to concentration limitations; it reports no new empirical results.
20 citations
,
January 2003 in “Treatments in Endocrinology” Testosterone therapy can help improve mood, sexual function, and bone health in women with low androgen levels, but more research is needed to establish safe and effective guidelines.
17 citations
,
January 1986 in “Acta obstetricia et gynecologica Scandinavica” In this study, spironolactone treatment reduced hair growth in 17 out of 30 patients with hirsutism, but was less effective compared to cyproterone acetate–estrogen therapy.
3 citations
,
January 2011 in “Female pelvic medicine & reconstructive surgery” This review discusses the impact of hormones on female sexual function and dysfunction, highlighting the complexity and gaps in basic research, and reports no new clinical findings.
January 2025 in “Journal of Men s Health” This article reports that the rise in erectile dysfunction among young men may be linked to mental health issues and societal pressures, with online communities often encouraging risky substance use like anabolic steroids and finasteride, which can exacerbate psychological and physical health problems.
February 2005 in “The Journal of Urology” This article evaluates sexual function using the International Index of Erectile Function in people taking finasteride for androgenetic alopecia but does not present new findings.
374 citations
,
May 2016 in “The Lancet. Diabetes & endocrinology” This article reviews the clinical complications and increased mortality risks associated with Cushing's syndrome but does not present new clinical data; it emphasizes the need for prompt treatment to mitigate these risks.
99 citations
,
June 1999 in “The Journal of Clinical Endocrinology and Metabolism” This commentary discusses the potential use of testosterone therapy for various conditions in women and reports no new clinical results; the authors advocate for more discussion and research in this area.
33 citations
,
January 2016 in “Skin appendage disorders” This review examines medical literature on postfinasteride syndrome and reports no new results; the authors call for more controlled studies on permanent sexual dysfunction and mood changes linked to 5-alpha-reductase inhibitors.
20 citations
,
September 2019 in “Epidemiology and Psychiatric Sciences” This review discusses post-SSRI sexual dysfunction syndrome and highlights its significant clinical and regulatory implications, but reports no new findings.
16 citations
,
July 2012 in “The New England Journal of Medicine” This case report describes a 27-year-old man hospitalized with fatigue, myalgias, weakness, profound weight loss, and abnormal liver function, leading to a diagnosis after chest imaging revealed pneumomediastinum.
14 citations
,
January 1990 in “Fertility and Sterility” In this study, five patients with moderate hyperprolactinemia lacked symptoms, signs, or underlying causes, leading researchers to conclude that no further investigation or therapy was needed.
11 citations
,
January 1995 in “Biomedicine & pharmacotherapy” This review discusses the use of finasteride and alpha antagonists for symptomatic benign prostatic hypertrophy and suggests current studies are evaluating combination therapies as potential non-surgical alternatives.
2 citations
,
March 2004 in “Reviews in Gynaecological Practice” This review discusses treatments for female sexual dysfunction in postmenopausal women, noting that the effectiveness of current pharmaceutical options is inconclusive and emphasizing the importance of individualized care.
6 citations
,
September 2020 in “Journal of Mind and Medical Sciences” This study found that vaginal surgical interventions for genital prolapse or urinary incontinence did not significantly alter the quality of sexual life in women, with a portion reporting improvement and others experiencing no change or decreased libido.
January 1983 in “Elsevier eBooks” This article reviews the discovery and various physiological effects of cyproterone acetate, reporting its established indications for several androgen-driven conditions but providing no new clinical data.
40 citations
,
April 1999 in “Drugs” This study concluded that finasteride is a viable first-line treatment for moderate uncomplicated benign prostatic hyperplasia, particularly in patients with larger prostates, by significantly reducing acute urinary retention and the need for surgery.
14 citations
,
January 2018 in “Advances in Clinical Chemistry” This review discusses the evaluation of hyperandrogenemia in women and hypogonadism in men across different life stages and presents biomarkers used for diagnosing male hypogonadism, reporting no new clinical results.
13 citations
,
November 2012 in “PubMed” This study found that in men with sexual dysfunction, use of 5ARI may reduce sexual drive and spontaneous erections without worsening pre-existing erectile or ejaculatory issues.
12 citations
,
January 2013 in “Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz” Older adults still engage in sexual activities but face challenges like health issues and lack of professional support, highlighting the need for better healthcare provider education and research on sexual fulfillment in old age.
6 citations
,
September 2005 in “Expert Opinion on Pharmacotherapy” This review discusses the role of androgens in women's sexual health and highlights the need for further research on androgen replacement therapy to optimize quality of life, but reports no new clinical results.
2 citations
,
January 2015 in “Springer eBooks” Environmental factors and exposure to toxins may contribute to male infertility by affecting sperm and hormone function.
1 citations
,
January 2015 in “Springer eBooks” AGA is a common hair loss disorder, and early diagnosis and treatment with minoxidil or finasteride can help reduce emotional distress.
January 2024 in “International Journal of Health Science” This literature review of hormonal implants in Brazil highlights their expanding usage beyond contraceptive and hormone replacement purposes, noting aesthetic desires like muscle mass gain. However, significant side effects such as cardiovascular events and psychological complications are frequently reported, potentially outweighing the benefits.
March 2023 in “Zdorov'â čolovìka” This article reviews how various medications, such as antihypertensives, chemotherapy, and hormonal contraceptives, are associated with negative effects on sexual desire and function but reports no new clinical results.
April 2015 in “Cambridge University Press eBooks” Many women experience sexual dysfunction, but few seek help, and better treatment and medical training are needed.
October 2007 in “Humana Press eBooks” This study reports that saw palmetto may effectively treat benign prostatic hyperplasia symptoms and potentially stimulate hair growth with generally mild side effects.
October 2007 in “Postgraduate obstetrics & gynecology” This article reviews the unapproved use of testosterone for treating female androgen insufficiency and reports no new clinical results.
32 citations
,
April 1999 in “Expert Opinion on Investigational Drugs” Clinical studies reported that finasteride reduces scalp dihydrotestosterone levels and improves hair growth in men with androgenetic alopecia, supporting its role as a treatment option.
November 2021 in “Permskij medicinskij žurnal” This study found that women with menstrual dysfunction showed higher rates of magnesium, iron, and vitamin D deficiencies compared to women with normal menstrual function.