November 2025 in “The Journal of Immunology” This study observed that in human scalp hair follicles, BTNL2 expression is lower in stressed conditions, which correlates with increased cytotoxic activity by gamma/delta and CD8+ T cells, suggesting a possible role for BTNL2 in controlling immune responses relevant to alopecia areata.
27 citations
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June 2020 in “Genes” This study identified multiple loss of function variants in the HR gene linked to the unique hair coat phenotype in lykoi cats, also known as werewolf cats.
January 2024 in “International Journal of Physics and Applications” This review discusses the therapeutic effects of soft laser therapy on humans and animals, highlighting increased ATP and reactive oxygen species production in cells with high mitochondrial activity.
7 citations
,
September 2014 in “European Journal of Dermatology” This study found a significant positive correlation between hair thickness and growth rate, with a notably slower growth rate observed in men with male pattern hair loss compared to healthy controls.
August 2025 in “Journal of Investigative Dermatology” Elevated luteinizing hormone contributes to female-pattern hair loss, and blocking certain channels may help prevent it.
10 citations
,
January 2010 in “Journal of cosmetic and laser therapy” This article describes a non-blinded study investigating low level laser therapy for seven patients but reports no new clinical findings.
2 citations
,
October 2014 in “International Journal of Trichology” Low-level laser therapy may increase hair density in pattern hair loss.
1 citations
,
June 2022 in “JCRPE” This study reports that metreleptin treatment in a boy with congenital generalized lipodystrophy significantly improved metabolic complications and overall health outcomes during the first year of therapy.
2 citations
,
January 2018 in “Recent clinical techniques, results, and research in wounds” This review discusses the effects of low-level laser therapy in various biological processes for wound healing and tissue repair and reports no new results.
This study observed that low-level laser therapy (LLLT) increased cell viability in SARS-CoV-2-uninfected HEK293/ACE2 cells but did not improve viability in infected cells, suggesting mixed effects.
11 citations
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January 2020 in “Skin appendage disorders” This study reviewed clinical trials and found that low-level laser therapy significantly increased hair diameter or density in both men and women with pattern hair loss compared to a sham device, though the involvement of industry relationships in some studies suggests cautious interpretation.
July 2024 in “Journal of Investigative Dermatology” Human hair follicles have their own thyroid hormone system.
37 citations
,
November 2019 in “Journal of Microbiology and Biotechnology” This study found that loliolide enhanced hair growth-related functions in 3D dermal papilla spheroids by activating AKT/β-catenin signaling pathways, with increased expression of related growth factors and genes.
35 citations
,
February 2003 in “Biochimica et Biophysica Acta (BBA) - General Subjects” This study found that lead treatment enhances the imaging of organized hair lipid structures, revealing their orientation and possible composition as lead and calcium soaps, with potential applications in various fields.
5 citations
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January 2017 in “Arquivos Brasileiros de Oftalmologia” This report describes a novel mutation in the CDH3 gene in an 11-year-old Iranian boy with hypotrichosis and juvenile macular dystrophy, indicating a new genetic variant associated with the disorder.
23 citations
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July 2016 in “JAMA Ophthalmology” This study observed that CDH3-related congenital hypotrichosis with juvenile macular dystrophy presents with childhood-onset progressive chorioretinal atrophy and universally thin and sparse scalp hair.
8 citations
,
April 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This study identified biallelic variants in the LSS gene as a possible genetic cause of palmoplantar keratoderma-congenital alopecia syndrome type 2, highlighting the role of cholesterol synthesis in skin cornification.
June 2026 in “British Journal of Dermatology” This case study documented the first known instance of biopsy-confirmed lichen planopilaris occurring after hairline-lowering surgery in a patient without prior history, highlighting a potential complication where surgical trauma may trigger immune-mediated hair loss.
1 citations
,
August 2016 in “Pan Stanford Publishing Pte. Ltd. eBooks” This chapter reviews low-level light therapy for hair growth and loss prevention but reports no new clinical results, providing an overview of mechanisms, treatments, and future perspectives.
2 citations
,
February 2018 in “Journal of bone oncology” This study found that low-dose chemotherapy for solitary bone lesions of Langerhans cell histiocytosis in children led to quicker recovery, higher quality of life at 3 months, and was more cost-effective compared to surgery.
April 2023 in “Journal of Investigative Dermatology” This study found that human TMEM2 does not function as a hyaluronidase but is involved in regulating hyaluronan metabolism.
7 citations
,
December 2014 in “Gynecological Endocrinology” This study found that LC-MS/MS is a more reliable method than immunoassays for measuring serum 17OHP and androgen levels in women with hyperandrogenism.
3 citations
,
May 2024 in “Cureus” This study found that LAHR significantly improves the quality of life in the short term for women with PCOS, but underscores a need for further research to develop long-term treatment strategies.
May 2024 in “Journal of cosmetic dermatology” This study investigated the effects of heat-treated Limosilactobacillus fermentum LM1020 on hair growth and reported increased hair density, improved cellular activity, and beneficial scalp microbiota changes in patients with androgenetic alopecia over 24 weeks.
February 2024 in “International Journal For Multidisciplinary Research” This review examines the advances in nanostructured lipid carriers for treating hyperpigmentation but presents no new clinical results; the authors highlight their potential benefits and applications.
178 citations
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October 2001 in “Genes & Development” This study found that the mammalian hairless gene encodes a corepressor protein that interacts with thyroid hormone receptors, providing insights into hair loss syndromes in humans and mice.
7 citations
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March 2015 in “British Journal of Dermatology” Applying minoxidil can help improve hair growth in people with hair loss caused by LIPH gene mutations.
January 2025 in “Dermatology Research and Practice” In this research, RNA expression analysis of scalp biopsies from lichen planopilaris patients revealed changes in specific genes after treatments with hydroxychloroquine, narrow band UVB, or low level laser light therapy, suggesting potential biomarkers and implicating M2 macrophages in the disease's immunopathogenesis.
February 2016 in “Acta Medica Marisiensis” This case study presents what is reportedly the first association of Graham Little-Lassueur Syndrome with chronic hepatitis C, observed in a 47-year-old female patient.
December 2023 in “Trials” In this randomized controlled trial involving breast cancer patients undergoing chemotherapy, this study investigated the efficacy of low-level light therapy for preventing hair loss, measuring outcomes like hair count and patient quality of life, but the abstract does not report specific results.