Graham Little-Lassueur Syndrome with Hypertrophic Lichen Planus in a Patient with Chronic Hepatitis C

February 2016 in “ Acta Medica Marisiensis ”

M.A. Badea, Corneliu-Florin Buicu, Anton Mihai Ţilea, Iudita Badea, Andreea Luciana Chiotoroiu, Vasile Adrian Mureșan, Silviu Horia Morariu

Graham Little-Lassueur Syndrome hypertrophic lichen planus lichen planopilaris cicatricial alopecia topical corticosteroids salicylic acid UVB phototherapy cryotherapy GLLS scarring alopecia topical steroids UVB therapy

TLDR A woman with chronic hepatitis C had a rare skin condition linked to her illness.

Graham Little-Lassueur Syndrome (GLLS) was reported in a 47-year-old female with chronic hepatitis C, poorly managed due to Interferon intolerance. She exhibited intensely pruritic erythematous plaques on her shins and cicatricial alopecia on her scalp. A skin biopsy confirmed hypertrophic lichen planus on the shins and lichen planopilaris on the scalp. Treatment included systemic antihistamines, topical corticosteroids, salicylic acid, emollients, UVB phototherapy, and cryotherapy. This case was notable as the first reported instance of GLLS associated with chronic hepatitis C.

View this study on content.sciendo.com →

Discuss this study in the Community →

Research cited in this study

1 / 1 results

research Graham Little-Piccardi-Lassueur Syndrome Associated with Androgen Insensitivity Syndrome (Testicular Feminization)

22 citations, June 2004 in “Journal of The European Academy of Dermatology and Venereology”

A woman had both Graham Little-Piccardi-Lassueur syndrome, causing hair loss, and complete androgen insensitivity syndrome, making her genetically male but physically female. This suggests androgens don't affect the hair loss condition.

Related Research

2 / 2 results

research Bold to Do — Bald to Be? Outcomes Decades After Harvesting the Scalp in Burned Children

5 citations, October 2018 in “Burns”

Most patients who had scalp skin removed for burns as children had normal hair growth and were satisfied years later.

research Incidental Syringomas of the Scalp in a Patient with Scarring Alopecia

4 citations, July 2015 in “Case Reports in Dermatology”

A woman with unexplained hair loss was found to have harmless skin tumors and a scarring hair loss condition, but the tumors didn't cause the hair loss.