Graham Little-Piccardi-Lassueur Syndrome Associated with Androgen Insensitivity Syndrome (Testicular Feminization)

In 2004, a unique case study was reported involving a 29-year-old woman who had both Graham Little-Piccardi-Lassueur syndrome and complete androgen insensitivity syndrome (CAIS). The former is characterized by cicatricial alopecia on the scalp, keratosis pilaris on the trunk and extremities, and non-cicatricial hair loss in the pubis and axillae. CAIS is a genetic disorder causing genetic males with XY karyotype to develop a female phenotype due to a lack of sensitivity in the peripheral androgenic receptors. This was the first reported case associating these two conditions. The study suggested that androgens do not influence the alopecia of Graham Little-Piccardi-Lassueur syndrome, and the coincidence of non-cicatricial alopecia in axillary and pubic hair in both conditions was notable. These findings expanded the understanding of Graham Little-Piccardi-Lassueur syndrome and its relationship with androgens.