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GlossaryComplete Androgen Insensitivity Syndrome (CAIS)

genetic condition causing male individuals to develop female traits

Complete Androgen Insensitivity Syndrome (CAIS) is a genetic condition where an individual who is genetically male (with one X and one Y chromosome) is resistant to male hormones called androgens. As a result, the person has the physical traits of a female but does not have a uterus or ovaries, and typically has undescended testes. This condition is caused by mutations in the AR gene, which affects the body's ability to respond to androgens.

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research Clinical, Hormonal, Behavioral, and Genetic Characteristics of Androgen Insensitivity Syndrome in a Brazilian Cohort: Five Novel Mutations in the Androgen Receptor Gene

174 citations, July 2003 in “The Journal of Clinical Endocrinology & Metabolism”

Five new mutations in the androgen receptor gene were found, helping to understand androgen insensitivity syndrome better.

research Female Pattern Hair Loss in Complete Androgen Insensitivity Syndrome

54 citations, February 2010 in “British Journal of Dermatology”

Hair loss in women may have causes other than hormones.

research Graham Little-Piccardi-Lassueur Syndrome Associated with Androgen Insensitivity Syndrome (Testicular Feminization)

22 citations, June 2004 in “Journal of The European Academy of Dermatology and Venereology”

A woman had both Graham Little-Piccardi-Lassueur syndrome, causing hair loss, and complete androgen insensitivity syndrome, making her genetically male but physically female. This suggests androgens don't affect the hair loss condition.

research Identification of Two Additional Novel Mutations in the AR Gene Associated with Severe Forms of Androgen Insensitivity Syndrome

1 citations, September 2019 in “Steroids”

Two new mutations in the AR gene linked to severe androgen insensitivity were found.

research Novel Androgen Receptor Gene Variant Containing a Premature Termination Codon in a Patient with Androgen Insensitivity Syndrome

1 citations, August 2019 in “Journal of pediatric & adolescent gynecology”

A new genetic change causing early stop in the androgen receptor gene was found in a patient with androgen insensitivity syndrome.

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community My 9 month progress on the big three

11 upvotes 6 years ago

A user shared their 9-month hair loss treatment routine, which includes using Minoxidil, taking Finasteride, and using sulfate-free conditioner and shampoo, along with a multi-vitamin and fish oil. They also avoid harsh environments and wear a hat in the sun to protect their hair.