Werewolf, There Wolf: Variants in Hairless Associated with Hypotrichia and Roaning in the Lykoi Cat Breed

June 2020 in “ Genes ”

Reuben M. Buckley, Barbara Gandolfi, Erica K. Creighton, Connor Pyne, Delia M. Bouhan, Michelle L. LeRoy, David A. Senter, Johnny R. Gobble, Marie Abitbol, Leslie A. Lyons

hypotrichia roaning Hairless gene HR gene genetic variants whole genome sequencing

Studysummary This study identified multiple loss of function variants in the HR gene linked to the unique hair coat phenotype in lykoi cats, also known as werewolf cats. Our plain-language summary of this paper — not a Tressless recommendation.

The study explored the genetic basis of the Lykoi cat breed's unique hypotrichia and roaning phenotype, characterized by sparse hair and a "werewolf" appearance. Researchers conducted whole genome sequencing on 171 samples, identifying six significant variants in the Hairless (HR) gene, including frameshift, missense, splice, and stop codon mutations. These genetic changes were linked to the breed's distinctive hair coat without significant health issues, except for lymphocytic mural folliculitis. The study confirmed that the Lykoi phenotype resulted from multiple HR gene mutations, providing insights into the genetic diversity within the breed and suggesting that breeders could use genetic testing to manage these variants.

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