LC-MS/MS Improves Screening Towards 21-Hydroxylase Deficiency

December 2014 in “ Gynecological Endocrinology ”

Urszula Ambroziak, Anna Kępczyńska-Nyk, Alina Kurylowicz, Aleksandra Wysłouch-Cieszyńska, E Małunowicz, Zbigniew Bartoszewicz, Agnieszka Kondracka, Radoslaw Jazwiec, Emilia Pawłowska, Magdalena Szcześniak, Michal Dadlez, Tomasz Bednarczuk

LC-MS/MS immunoassays serum 17-hydroxyprogesterone 17OHP androgens hyperandrogenism total testosterone androstendione DHEA-S PCOS idiopathic hyperandrogenism CAH ACC liquid chromatography-tandem mass spectrometry polycystic ovary syndrome congenital adrenal hyperplasia adrenocortical carcinoma

Studysummary This study found that LC-MS/MS is a more reliable method than immunoassays for measuring serum 17OHP and androgen levels in women with hyperandrogenism.

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