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Different types of stem cells with unique roles exist in blood, skin, and intestines, and this variety is important for tissue repair.

Eating less can improve stem cell function and increase lifespan.

Stem cell plasticity is crucial for wound healing but can also contribute to cancer development.

Krt15+ cells in the mouse intestine resist radiation and can start tumors.

Different types of stem cells exist within individual skin layers, and they can adapt to damage, transplantation, or tumor growth. These cells are regulated by their environment and genetic factors. Tumor growth is driven by expanding, genetically altered cells, not long-lived mutant stem cells. There's evidence of cancer stem cells in skin tumors. Other cells, bacteria, and genetic factors help maintain balance and contribute to disease progression. A method for growing mini organs from single cells has been developed.

The niche environment controls stem cell behavior and plasticity, which is important for tissue health and repair.

Understanding where cancer cells come from helps create better prevention and treatment methods.

Hairless mammals have genetic changes in both their protein-coding and regulatory sequences related to hair.

LGR5 and LGR6 are expressed differently in various skin tumors, which may offer clues about their origins.

RSPO1 mutations in certain patients lead to skin cells that don't develop properly and are more likely to become invasive, increasing the risk of skin cancer.

High levels of the protein Flightless I worsen ulcerative colitis symptoms in mice.

Lysophospholipids like LPA and S1P are important for hair growth, immune responses, and vascular development, and could be targeted for treating diseases.

Lgr5 is a marker for active, self-renewing stem cells in the intestine and skin, important for tissue maintenance.

New methods have greatly improved our understanding of stem cell behavior and roles in the body.

Wnt signaling is important for development and cell regulation but can cause diseases like cancer when not working properly.

Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.

Certain proteins, Lgr5 and Lgr6, are important markers of adult stem cells and are involved in tissue repair and cancer development.

Stem cells regenerate tissues and their behavior varies by environment, suggesting the hematopoietic system model may need revision.

Targeting colon cancer stem cells might lead to better treatment results.

Stem cell self-renewal is complex and needs more research for full understanding.

Some stem cells in the body rarely divide, which could help create better treatments for diseases and aging.

Paneth cells and intestinal stem cells work together metabolically for stem cell function and regeneration.

Stem cell offspring help control their parent stem cells, affecting tissue health, healing, and cancer.

Epigenetic changes control how adult stem cells work and can lead to diseases like cancer if they go wrong.

Eating fewer calories improves the ability of stem cells to repair and renew the body in various tissues.

The document concluded that stem cells are crucial for skin repair, regeneration, and may help in developing advanced skin substitutes.

Compartmentalized organization might be crucial for stem cells to effectively respond to growth or injury.

Metabolism plays a key role in determining stem cell fate.

Stem cell niches are crucial for regulating stem cell behavior and tissue health, and their decline can impact aging and cancer.

TGF-β signaling is crucial for stem cell maintenance, differentiation, and has implications for cancer treatment.