3 citations
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September 2015 in “Journal of Vascular Surgery” This study found that chemical lumbar sympathectomy with 5% phenol effectively treated idiopathic livedo reticularis in most patients, offering a potential long-lasting solution with repeatable efficacy upon recurrence.
January 2011 in “Xibei nongye xuebao” This study found that the K14 promoter exhibited higher activity in skin cell lines compared to other cell lines, while both K14 and K5 promoters were active in all tested cell lines.
November 2025 in “Journal of Investigative Dermatology” PCFCL may have unrecognized subtypes and needs more research.
2 citations
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November 1996 in “Transplantation” This study found that intrathymic injection of recipient-type splenocytes into donor rats, combined with antilymphocyte antiserum, effectively prevented graft-versus-host disease for up to 300 days.
38 citations
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January 2016 in “Cell Death and Disease” This review discusses the role of the TCL1 transgenic mouse model in understanding chronic lymphocytic leukemia biology and highlights the importance of exploring new pathogenetic and therapeutic targets.
April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” This study revealed distinct cellular and transcriptomic differences among various subtypes of cutaneous T-cell lymphoma, particularly highlighting characteristics unique to folliculotropic mycosis fungoides.
September 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” The researchers reported that TGM2 appears to play a crucial role in sebocyte differentiation and may act as a negative regulator of lipid metabolism in sebaceous glands.
October 2009 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” This study demonstrates that using a K15 promoter-driven GFP labeling technique allows for the identification and characterization of epithelial stem cells in adult human hair follicles.
This study identified a high proportion of dual TCR Treg cells in both lymphoid and non-lymphoid tissues of mice, revealing their tissue specificity, TCR repertoire characteristics, and functional phenotypes.
37 citations
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March 2006 in “Regulatory Peptides” This study reports that GLP-1 receptors and proglucagon are expressed in the skin of newborn mice, with GLP-1 potentially playing a role in skin development and hair follicle formation.
153 citations
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October 2007 in “Cell Stem Cell” New research suggests that skin cell renewal may not require a special type of cell previously thought to be essential.
3 citations
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May 2020 in “Journal of Cellular and Molecular Medicine” This study identified critical roles for the gene GREM1 in the differentiation and expansion of endothelial progenitors derived from human urinary induced pluripotent stem cells.
15 citations
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May 2003 in “The Laryngoscope” In this study, researchers observed that spiral ganglion neurites created more branched networks near FGF-1-coupled beads compared to control beads, highlighting FGF-1's role in hair cell innervation development.
91 citations
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May 2005 in “The Journal of Clinical Endocrinology & Metabolism” In this study, a novel mutation in the glucocorticoid receptor gene was identified in a young woman, impairing glucocorticoid signaling and leading to generalized glucocorticoid resistance.
April 2018 in “Journal of Investigative Dermatology” This study suggests that the Leptin receptor may serve as a novel cell surface marker for dermal papilla cells, potentially aiding future isolation and research efforts in hair follicle regeneration studies.
19 citations
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January 2007 in “Journal of medical investigation” This study found that transplanting GFP transgenic tail skin onto wild-type mice leads to partial replacement of dermis, nerves, and blood vessels by recipient tissue after six months, while epidermis, hair follicles, and sebaceous glands persist from the graft.
January 2025 in “PLoS ONE” This study found that ING5 knockout mice are prone to developing lymphomas and severe dermatitis, suggesting ING5 plays a role in tumor suppression and stem cell maintenance in vivo.
13 citations
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September 2012 in “Cell & tissue research/Cell and tissue research” In this study, researchers found that the pCLCA2 protein is expressed in specific areas of pig skin, but its role in skin structure or function remains unclear.
18 citations
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May 2011 in “Journal of Investigative Dermatology” Wnt signaling affects the development and growth of Langerhans cells in mice.
1 citations
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December 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that Sox9 plays a critical role in maintaining radial glial progenitor cells and regulates the timing of their generation of upper-layer cortical neurons.
18 citations
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January 2013 in “Evidence-based Complementary and Alternative Medicine” In this study, ALR was found to enhance both the proliferation and osteogenic differentiation of mouse bone marrow mesenchymal stem cells, potentially through specific signaling pathways.
5 citations
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May 2024 in “Developmental Cell” Lower GATA3 levels in mice help hair regrow by changing certain immune cells.
May 2022 in “Journal of Immunology” In this study, a TGF-β mimic molecule from Heligmosomoides polygyrus was observed to enhance wound healing in mice, with improved tissue regeneration and specific immune cell recruitment without increased scarring.
1 citations
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January 2024 in “Nature communications” This study found that stimulating toll-like receptor 5 via mucosal delivery of a flagellin-containing fusion protein effectively extended lifespan and enhanced healthspan in mice, including improved bone density and cognitive capacity.
42 citations
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December 2011 in “The journal of immunology/The Journal of immunology” In this study, transgenic mice with Rank expression in hair follicles showed excessive lymph node growth, which could be normalized by neutralizing the overproduced RANKL, underscoring its role in immune system regulation.
1 citations
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December 2022 in “Frontiers in Immunology” This review summarizes recent findings about the multi-site differentiation of tissue regulatory T cells, emphasizing the pivotal role of epigenetic remodeling, but it reports no new clinical results.
96 citations
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December 2002 in “Experimental dermatology” This study found that NGAL expression in embryonic skin is spatio-temporally regulated and strongly induced in adult skin conditions with dysregulated differentiation, suggesting a role in epithelial differentiation pathways.
January 2008 in “Infoscience (Ecole Polytechnique Fédérale de Lausanne)” In this study, rat primary thymic epithelial cells demonstrated a clonogenic growth pattern in vitro and were able to integrate into functional thymus or differentiate into skin derivatives, similar to skin multipotent stem cells.
April 2023 in “Journal of Investigative Dermatology” In this study, researchers developed a mouse model of scarring alopecia and observed significant reductions in CD200R expression in affected skin, potentially linking this signaling pathway to immune attacks on hair follicles and suggesting new treatment targets for scarring hair loss.
71 citations
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May 2019 in “Rheumatology” This study observed that PD-1+CXCR5-CD4+T peripheral helper cells are significantly elevated in patients with systemic lupus erythematosus and are correlated with disease activity indicators, suggesting their potential role in lupus pathogenesis.