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Long-term testosterone therapy can cause hormone suppression, affect prostate and heart health, and alter physical characteristics, but does not increase prostate cancer risk and needs more research for full risk assessment.

Insulin resistance may contribute to various skin diseases and treating it could improve skin health and prevent more serious conditions.

Janus kinase inhibitors are promising drugs for treating autoimmune and inflammatory diseases.

The document explains how the male reproductive system works, its role in making testosterone, and how conditions like obesity can disrupt it, leading to low testosterone and fertility issues.

Blocking the enzyme 11β-HSD1 might help treat obesity and metabolic issues.

An imbalance between certain immune cells is linked to a chronic skin condition and may be influenced by obesity, smoking, and autoimmune issues.

The document concludes that for hair and feather growth, it's better to target the environment around stem cells than the cells themselves.

Skin problems can be caused or worsened by physical forces and pressure on the skin.

Skin fat has important roles in hair growth, skin repair, immune defense, and aging, and could be targeted for skin and hair treatments.

Light can turn on hair growth cells through a nerve path starting in the eyes.

Brain hormones significantly affect hair color and could potentially be used to prevent or reverse grey hair.

Some skin conditions may indicate metabolic syndrome, which could help with early detection and management of related health issues.

Glutamine metabolism affects hair stem cell maintenance and their ability to change back to stem cells.

Botox increased hair count in men with baldness and might work by improving scalp blood flow.

Eating healthy, exercising, and taking certain supplements can help manage Polycystic Ovary Syndrome symptoms.

Skin fat plays a key role in immune defense and healing beyond just storing energy.

Women with regular menstrual cycles and PCOS have linked kisspeptin and LH hormone patterns, unlike those with irregular cycles.

The conclusion is that genetic changes in the glucocorticoid receptor can lead to conditions affecting stress response, immunity, and metabolism, requiring personalized treatment.

The document concludes that future heart disease research should account for sex-specific differences to improve diagnosis, treatment, and outcomes.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

Lifestyle changes are the main treatment for PCOS, which is a complex condition requiring early management to reduce its health impacts.

Hair follicles can help wounds heal faster and this knowledge could be used to treat chronic skin ulcers, with a potential use of a special stem cell hydrogel to enhance healing.

Adult female acne requires a comprehensive treatment approach, including medical options and lifestyle changes, with attention to psychological well-being.

Fat cells are important for tissue repair and stem cell support in various body parts.

PFS and PSSD are similar conditions with persistent sexual dysfunction after stopping medication.

JAK inhibitors show promise for treating skin and hair disorders but need more research on long-term safety and effectiveness.

The skin is the largest organ, protecting the body, regulating temperature, and producing hormones.

The French Endocrine Society suggests diagnosing PCOS with two of three signs, recommends lifestyle changes and clomiphene for treatment, and calls for more research on certain treatments and tests.

Weight loss and metformin don't significantly change vaspin levels in women with PCOS.

The document concludes that treating PCOS requires a combination of drugs to manage reproductive and metabolic symptoms, with more research needed on combination therapies.