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The Endocrine Society advised against routine testosterone therapy for women, citing a need for more research on long-term safety and a clear definition of androgen deficiency.

The document concludes that insulin resistance is key in PCOS development and early treatment is crucial to prevent complications.

Insulin resistance is a key factor in polycystic ovary syndrome, but genetics may also contribute.

Fat cells help recruit healing cells and build skin structure during wound healing.

Metformin helps manage polycystic ovary syndrome by improving insulin resistance and ovulation, but more research is needed on its full effects.

High levels of male hormones, insulin resistance, and obesity are closely linked and worsen polycystic ovary syndrome, but more research is needed to improve treatments.

Hormone treatments for transgender individuals generally improve mental health and physical transition, with some health risks that require medical supervision.

Stem cell niches support, regulate, and coordinate stem cell functions.

Testosterone therapy in transgender men has both desired effects like increased muscle mass and potential health risks such as higher cardiovascular risk.

Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.

Postpartum depression is linked to changes in brain chemicals, inflammation, stress, and certain genes, and can potentially be identified by markers like specific steroids, serotonin levels, and vitamin D levels.

Fat-derived stem cells show promise for skin repair and reducing aging signs but need more research for consistent results.

Obesity worsens PCOS symptoms, and PCOS may lead to more weight gain; managing both requires a holistic approach that includes mental health.

Stem cell plasticity is crucial for wound healing but can also contribute to cancer development.

Modern lifestyles, including poor diet, stress, and long-term use of certain medications, hinder the body's ability to heal from inflammation, leading to chronic diseases.

People with PCOS, especially if obese, often have NAFLD, linked to obesity, insulin resistance, and high androgen levels.

Lignans and neolignans from plants may help protect against various health issues, including cancer and heart disease.

The document concludes that understanding the sebaceous gland's development and function is key to addressing related skin diseases and aging effects.

The document concludes that certain genetic mutations and dietary factors are involved in acne development, and treatments like isotretinoin and diet changes can help manage it.

The sebaceous gland has more roles than just producing sebum and contributing to acne, and new research could lead to better skin disease treatments.

Hormones significantly affect hair and oil gland function in the skin, and more research is needed on skin-related hormone disorders.

Skin fat helps with body temperature control and has other active roles in health.

Obesity increases the risk of developing polycystic ovary syndrome, and weight loss can improve the condition.

The document concludes that understanding the genes and pathways involved in hair growth is crucial for developing treatments for hair diseases.

Women with PCOS may take longer to get pregnant but can have a normal family size, and should manage their overall health to reduce long-term health risks.

Effective hair loss treatment in women requires correct diagnosis and can include medications like minoxidil, antiandrogens, and treatments for underlying conditions like PCOS.

Muscles and nerves that cause goosebumps also help control hair growth.

New treatments for male hypogonadism are effective and should be personalized.

Hormones, especially androgens, play a key role in acne, which can be a symptom of systemic diseases like PCOS and may require targeted treatment.

Some heart drugs show promise for other conditions, but more research is needed to confirm their effectiveness and safety.