8 citations
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January 2020 in “Skin appendage disorders” This review found that supplements containing saw palmetto may improve hair quality and density in patients with androgenetic alopecia and telogen effluvium, but more large-scale RCTs are needed for conclusive evidence.
6 citations
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January 2016 in “Evidence-based complementary and alternative medicine” In this study, saw palmetto supplements showed varied effects on cell growth in vitro and did not significantly inhibit growth in the hamster flank organ model despite a notable trend.
6 citations
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March 2014 in “Herba Polonica” This article reviews treatment options for androgenetic alopecia, highlighting potential uses of plant materials, but reports no new clinical results.
6 citations
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October 2012 in “Pediatrics” This case report describes an 11-year-old girl who experienced hot flashes and menarche after taking a Serenoa repens supplement for telogen effluvium, suggesting a possible but uncertain link between the supplement and hormonal changes.
6 citations
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May 2011 in “Pharmacognosy Journal” This review discusses the causes of alopecia, including androgenetic alopecia, and potential active ingredients for hair regrowth, but it does not report new clinical results.
5 citations
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August 2005 in “Current Urology Reports” Saw palmetto helps with nighttime urination and urine flow, similar to finasteride.
3 citations
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January 2019 in “Therapeutic advances in urology” This review concluded that WS PRO 160 I 120 mg, a herbal preparation, may be an effective and safer alternative to standard drugs for treating lower urinary tract symptoms in men with benign prostatic hyperplasia.
3 citations
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November 2018 in “Journal of cellular physiology” In laboratory settings, this study suggests that Serenoa repens and N-acetyl glucosamine with milk proteins may promote hair follicle vascularization through specific cellular interactions and actions.
3 citations
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February 2008 in “Basic and clinical dermatology” Telogen Effluvium is a hair loss condition where treatment involves identifying and managing its triggers.
2 citations
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December 2003 This article discusses Serenoa repens (Saw palmetto) for preventing and treating androgenic alopecia, highlighting its phytosterols' role and lack of side effects but reports no new clinical results.
1 citations
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October 2015 in “CRC Press eBooks” Nutricosmetics with active ingredients can help with hair loss and improve hair growth.
November 2025 in “Frontiers in Pharmacology” This mini-review examines ethnopharmacological approaches to manage hair loss in postmenopausal women, highlighting promising botanical remedies like saw palmetto, rosemary oil, and ginseng. The authors underscore a need for more interdisciplinary trials and focus on traditional remedies' multifaceted benefits, while noting gaps in menopausal-specific evidence.
November 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that disrupted cholesterol homeostasis impairs hair regrowth in individuals with primary cicatricial alopecia by damaging hair follicle stem cells, highlighting the importance of cholesterol in maintaining stem cell function and hair follicle integrity.
This chapter reviews the uses and evidence for saw palmetto in treating lower urinary tract symptoms in men with benign prostate hyperplasia, but finds no strong support for its effect on hair loss.
January 2015 in “Hair therapy & transplantation” This review discusses natural and botanical products examined for treating alopecia and reports no clinical results; the authors note growing research interest in these treatments.
This review discusses potential cosmeceutical treatments for hair loss, including ingredients like procyanidins and isoflavones, but does not present new clinical outcomes; the authors highlight the promise of further research.
July 2011 in “Springer eBooks” This review discusses both conventional and new pharmaceutical treatments for hair loss, as well as various natural and herbal remedies, but reports no new clinical results.
September 2008 in “UK vet. Companion animal” This article updates on the medical management of benign prostatic hyperplasia in companion animals and reports no new clinical findings; the authors discuss existing treatments.
June 2001 in “International Journal of Cosmetic Surgery and Aesthetic Dermatology” This review discusses advances in 5α-reductase inhibitors for treating male androgenetic alopecia and reports no new clinical results.
November 2024 in “Postępy Biochemii” This article highlights the potential for latanoprost acid, a metabolite of the glaucoma medication latanoprost, to serve as an effective alternative to current treatments for androgenetic alopecia, such as minoxidil and finasteride, facilitating a faster development process for related drugs.
March 2023 in “Reactions Weekly”
12 citations
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January 2009 in “Journal of Oleo Science” The researchers reported that sterol surfactants with a bulky planar structure effectively solubilized ultraviolet ray absorbers, offering a stable solution more efficiently than other surfactants.
January 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This study reports the discovery of LX-38, a novel non-steroidal drug candidate that may offer safer treatment for conditions like Benign Prostatic Hyperplasia by avoiding hormonal side effects associated with current therapies.
November 2022 in “International Journal of Applied Pharmaceutics” This study found that phytosterols extracted from moringa seed oil may act as potential anti-alopecia agents by inhibiting the 5α-reductase enzyme, with ergostadienol showing particularly high affinity and stability in in silico simulations.
January 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This study reports the discovery of LX-38, a new high-affinity non-steroidal antagonist that could provide the therapeutic benefits of current BPH and AGA treatments without the hormonal side effects, utilizing a distinct "Orthogonal T-Stacking" scaffold for binding.
October 2023 in “Journal of the American Academy of Dermatology” This source reports that clascoterone cream has been approved in the U.S. for treating acne vulgaris in patients aged 12 and older, suggesting it works by competing with dihydrotestosterone at androgen receptors to mitigate acne's effects.
January 2025 in “International Journal of Pharmacognosy and Clinical Research” This study reported the development of a scalp serum containing Beta-Sitosterol and nutrient-rich oils, showing stable physicochemical properties, suggesting potential for promoting hair growth and scalp health, though further clinical testing in humans is needed to confirm effectiveness.
4 citations
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October 2024 in “Heliyon” This study characterized the CYP154C7 enzyme from *Streptomyces* sp. PAMC26508, highlighting its ability to hydroxylate steroids efficiently, particularly androstenedione, and identified key amino acids important for substrate selectivity and catalytic efficiency.
7 citations
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January 2022 in “Bioengineering” This study found that a lipid-based nanoparticle formulation with oleic acid for delivering dutasteride showed lower skin permeation compared to a formulation without oleic acid, indicating its potential for targeted dermal delivery.
6 citations
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May 2022 in “Chemistry & biodiversity” This study identified compounds from Laportea bulbifera with potential inhibitory effects on human steroid 5α-reductase 2, suggesting their application in treating benign prostatic hyperplasia.