Will a Glaucoma Drug Revolutionize Androgenetic Alopecia Treatment? On Repurposing a Drug Whose Side Effect Became a Desired Therapy Outcome.

    November 2024 in “ Postępy Biochemii
    Kalina Spławska, Łukasz Zybaczyński, Maciej Wierzbicki, Katarzyna Koziak
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    TLDR Latanoprost may be a promising new treatment for hair loss.
    The article discusses the potential of latanoprost, a synthetic analog of prostaglandin F2α originally used to treat glaucoma, as a treatment for androgenetic alopecia. Latanoprost's side effect of excessive eyelash growth has led to interest in its active metabolite, latanoprost acid, as a promising alternative to minoxidil and finasteride, the only currently registered treatments for this type of hair loss. The development of hair loss treatments containing prostaglandin derivatives, including latanoprost acid, is expected to be faster than traditional drug development processes.
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      in Research/Science  3 upvotes 2 weeks ago
      DLQ01, a prostaglandin F2α analog, shows promise for hair growth by directly stimulating PGE2/PGF receptors without needing conversion, and can be combined with minoxidil and retinoids like tretinoin for enhanced effectiveness. Minoxidil's efficacy may be reduced by COX-1 inhibitors, but using prostaglandin analogs like Latanoprost or Bimatoprost can help maintain its effectiveness.

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      in Treatment  3 upvotes 2 months ago
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