Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study from ISTAP emphasizes the importance of preventing skin tears, particularly in vulnerable populations like older adults and neonates, and recommends strategies such as using silicone-based adhesives, emollient therapy, and maintaining a safe environment to reduce the risk of these injuries.

This study observed that Trps1 gene expression in mice is precisely regulated in skin development, particularly during hair follicle morphogenesis, with distinct localization patterns in different cell types.

This study reports that daily topical application of a 0.05% tretinoin solution can eliminate the hair plugs and symptoms associated with trichostasis spinulosa.

This study describes the expression patterns of type I inner root sheath keratin proteins K25–K28 in human hair follicles, highlighting their distinct distribution within different layers.

This study identified a new keratin, K6irs, as a potential histological marker for the inner root sheath of hair follicles in mice and humans, and as a candidate gene for hereditary hair defects.

This study observed that conjugates of the anticancer drug raltitrexed with dextran and albumin were more cytotoxic than the free drug at high concentrations, altering cell cycle effects.

This review discusses the progress and challenges of targeted protein degradation therapies, highlighting the increasing number of degraders in cancer clinical trials and the limited diversity in targeted proteins, primarily focusing on those employing CRL4^CRBN as the E3 ligase.

This review highlights recent progress in developing androgen receptor degraders, such as PROTACs, for treating castration-resistant prostate cancer, and notes that several have entered phase I or II clinical trials, showcasing potential to address drug resistance challenges.

This study found that a short-term treatment with all-trans retinoic acid may effectively stabilize platelet counts in idiopathic thrombocytopenic purpura patients experiencing fluctuations during thrombopoietin receptor agonist therapy.

This study evaluated the long-term effects of combining autologous platelet-rich stroma injection with transanal advancement flap repair for cryptoglandular transsphincteric fistulas and found that it resulted in primary clinical closure and radiological healing in a high percentage of patients, with low recurrence rates.

This study suggests that autophagy is essential for regulating TLR3-mediated regenerative processes in human keratinocytes.

This paper reviews current cell therapies in medicine, highlighting hematopoietic stem cell transplants as a foundational success and the growing application of genetically modified cells like CAR-T and mesenchymal stem cells for various diseases, including blood disorders and autoimmune conditions.

In this study using mouse models, researchers found that stress-related hair loss may occur due to CRH-induced PTEN loss and inhibition of autophagy via the PI3K/AKT/mTOR pathway in dermal papilla cells, suggesting potential treatments through PTEN activation or autophagy enhancement.

This study found that supplementing with 1.5% α-ketoglutaric acid significantly improved the performance, hair follicle density, and antioxidant capacity in Rex rabbits, potentially by enhancing the Wnt signaling pathway and reducing amino acid catabolism.

Krox20 is crucial for hair growth and maintaining skin stem cells.

This study identifies two previously unreported pathogenic RIPK4 gene variants, suggesting a functional link with cell adhesion molecules in ectodermal dysplasias.

This article reviews the clinical features of dermatopathia pigmentosa reticularis, highlighting its characteristic triad of symptoms, but provides no new research results.

This study identified a compound heterozygous mutation in a hairless rhesus macaque, which was associated with skin abnormalities similar to those in hairless mice and humans with APL.

This study found that Plakophilin 1 regulates innate immune responses in keratinocytes by controlling RNA helicase activity, balancing inflammation during epidermal immune challenges.

This article discusses Trikostazis spinuloza (TS), a dermatological condition often misdiagnosed, and reviews its demographic, clinical, and dermoscopic features, but reports no new clinical results.

This study suggests that the KAP 7 gene may serve as a potential molecular marker for genetic selection to improve staple length and greasy fleece weight in Rambouillet sheep.

This review examines compounds that activate IK1 channels, highlighting their potential for developing Kir channel agonists and addressing safety concerns, but does not report new experimental findings.

This study sequenced a related gene to KRT2.9 called KRT2.13, which encodes a type II keratin protein not expressed in the hair follicle, and found significant sequence homology suggesting possible gene conversion or conservation of functional sequences.

This study found that decreased TRPS1 expression in balding dermal papilla cells may impair their signaling ability, contributing to hair follicle miniaturization in androgenic alopecia.

This study identified a missense mutation in the keratin 71 gene as the cause of autosomal dominant woolly hair/hypotrichosis in a Japanese family, marking the first human mutation in KRT71 linked to a hair disorder.

This study found that stress-related hair loss may be driven by CRH-mediated mechanisms that inhibit autophagy and increase apoptosis in dermal papilla cells, suggesting potential therapeutic targets like PTEN activation or rapamycin to enhance autophagy.

In this study, researchers identified nine new sheep keratin genes, highlighting species-specific differences in the expression and compartmentalization of wool-related keratin genes compared to humans.

This study identified a new cytokeratin, mK6irs, specifically expressed in the inner root sheath of mouse hair follicles, distinguishing it as a member of the type II cytokeratin family.

This case study documents the co-existence of trichorhinophalangeal syndrome and loose anagen syndrome in a patient, highlighting a previously unreported association between the two conditions.