Association of Trichorhinophalangeal Syndrome and Loose Anagen Syndrome: A Case Report

The document describes the first known case of a family with both Trichorhinophalangeal syndrome (TRPS) and Loose Anagen Syndrome (LAS). TRPS is a genetic disorder affecting hair, facial features, and bones, while LAS causes hair to be easily pulled out in children. The study focused on a 6-year-old girl displaying symptoms of both conditions, such as thin hair, distinctive facial features, and short fingers. Trichoscopy, a method of examining hair and scalp, showed unique black granular structures indicative of LAS. The girl's father and other relatives also showed signs of both TRPS and LAS, suggesting a genetic link. The study highlights the importance of these black rectangular structures in diagnosing LAS and calls for further research to confirm these findings.