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    Glossary TRPS1

    genetic disorder causing sparse hair and skeletal abnormalities

    TRPS1 stands for "Trichorhinophalangeal Syndrome Type 1," which is a genetic disorder characterized by distinctive facial features, abnormalities in the fingers and toes, and sparse scalp hair. It is caused by mutations in the TRPS1 gene, which plays a role in the development of bones and hair follicles. This condition can lead to alopecia (hair loss) and other skeletal abnormalities.

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    Research 10 of 123

    1. A position effect on TRPS1 is associated with Ambras syndrome in humans and the Koala phenotype in mice 2008 · 60 citations
    2. Trps1 activates a network of secreted Wnt inhibitors and transcription factors crucial to vibrissa follicle morphogenesis Development · 2011 · 59 citations
    3. The function of TRPS1 in the development and differentiation of bone, kidney, and hair follicles. PubMed · 2011 · 52 citations
    4. Dynamic expression of the zinc-finger transcription factor Trps1 during hair follicle morphogenesis and cycling Gene Expression Patterns · 2007 · 46 citations
    5. Trichorhinophalangeal syndrome with low expression of TRPS1 on epidermal and hair follicle epithelial cells The Journal of Dermatology · 2013 · 16 citations
    6. New case of trichorinophalangeal syndrome-like phenotype with a de novo t(2;8)(p16.1;q23.3) translocation which does not disrupt the TRPS1 gene BMC medical genetics · 2014 · 9 citations
    7. TRPS1 haploinsufficiency results in increased STAT3 and SOX9 mRNA expression in hair follicles in trichorhinophalangeal syndrome Journal of Dermatological Science · 2016 · 2 citations
    8. A Case of Tricho-rhino-phalangeal Syndrome Caused by a Novel Heterozygous Nonsense Mutation in the TRPS1 Gene 2024
    9. Novel frameshift mutation in TRPS1 in a ukrainian patient with trichorhinophalangeal syndrome type I International Journal of Trichology · 2013
    10. 746 Transcriptomic profiling of frontal and occipital dermal papilla reveals potential role of TRPS1 in androgenic alopecia Journal of Investigative Dermatology · 2022
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    Community 2

    1. Proof DHT is not the main cause of hair loss. TRPS1 Gene and Protein might be. PP405 won’t work. AMP-303 might! Reddit · 10 Mar 2026
    2. DHT Isn’t the Only Factor in Hair Loss and That Might Be the Key to a Real Cure Reddit · 6 Mar 2026

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