The Function of TRPS1 in the Development and Differentiation of Bone, Kidney, and Hair Follicles
July 2011
in “
PubMed
”
TLDR TRPS1 is crucial for bone, kidney, and hair follicle development.
The review discussed the role of the TRPS1 gene, which encodes a GATA-type transcription factor with nine zinc-finger motifs, in the development and differentiation of bone, kidney, and hair follicles. Mutations in TRPS1 were linked to Tricho-rhino-phalangeal syndrome, affecting skeletal development. Studies using TRPS1Δgt and Trps1-deficient mice revealed that TRPS1 played a crucial role in cartilage by regulating chondrocyte differentiation, proliferation, and apoptosis. In kidney development, TRPS1 functioned downstream of BMP7, influencing nephron formation and suppressing renal fibrosis by decreasing Arkadia expression. In hair follicles, TRPS1 was expressed in dermal papillae and mesenchymal cells, with its loss significantly impacting hair follicle development. The review highlighted the diverse functions of TRPS1 in these tissues.
