Transcriptomic Profiling of Frontal and Occipital Dermal Papilla Reveals Potential Role of TRPS1 in Androgenic Alopecia

July 2022 in “ Journal of Investigative Dermatology ”

Saurav Limbu, Nilofer Farjo, Bessam Farjo, Peter D. Kemp, Charles B. Higgins

TRPS1 androgenic alopecia dermal papilla frontal dermal papilla occipital dermal papilla keratin 75 androgen receptor hair follicle miniaturization anagen telogen AGA DP FDP ODP K75 AR

TLDR TRPS1 loss in balding scalp areas contributes to hair loss in androgenic alopecia.

The study investigates the role of TRPS1 in androgenic alopecia (AGA) by comparing dermal papilla (DP) cells from balding (frontal, FDP) and nonbalding (occipital, ODP) scalp regions. Using an in vitro double spheres assay, it was found that FDP cells induce a 1.23X reduction in the hair marker keratin 75 (K75) expression compared to ODP cells, indicating impaired BC differentiation ability in FDP. Transcriptomic analysis revealed a 1.7X upregulation of TRPS1 in ODP compared to FDP, which remained significant but reduced to 1.2X in cultured spheres. Knocking down TRPS1 in ODP resulted in a 1.1X reduction in K75 expression, suggesting TRPS1's role in DP signaling to BC. Activation of the androgen receptor (AR) in DP spheres led to a 2X decrease in TRPS1, implicating androgens in TRPS1 loss in FDP. The data supports that TRPS1 loss in FDP contributes to hair follicle miniaturization in AGA by impairing DP's signaling to BC during the anagen to telogen transition.

View this study on jidonline.org →

Discuss this study in the Community →

Related Community Posts Join

6 / 6 results

community Do hair follicles dies or are dormant ?

in Finasteride/Dutasteride 92 upvotes 4 weeks ago

Hair follicles can be dormant and potentially revived with treatments like finasteride and minoxidil, but irreversible loss occurs if certain structures are destroyed. Early intervention is more effective, and additional methods like microneedling may help.

Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

in Research 411 upvotes 2 weeks ago

Treating androgenic alopecia with minoxidil, finasteride, and antiandrogens, alongside exercise, cryotherapy, and natural substances to stimulate cold receptors for better hair growth. The method focuses on enhancing treatment effectiveness by considering environmental and behavioral factors and the role of cold receptors and muscle stress.

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens.

in Research/Science 1 upvotes 2 weeks ago

A method for treating androgenic alopecia using minoxidil, antiandrogens, exercise, and cold exposure to promote hair growth. Environmental factors and lifestyle changes, like diet and exercise, can improve treatment effectiveness.

community NW6 - 12 months progress - Dut/Oral Min/2% Keto Shampoo

in Progress Pictures 141 upvotes 5 months ago

User shared 12-month hair loss progress using oral minoxidil, oral dutasteride, and 2% ketoconazole shampoo. They detailed their medication regimen and dosages.

community Progress pictures: March 2024-October 2024.

in Progress Pictures 414 upvotes 1 month ago

The user experienced significant hair regrowth using topical minoxidil 5% twice daily and 1mg finasteride daily, along with microstamping every 14 days. They reported initial shedding but achieved satisfying results by month four, with minimal side effects.

community Oxytocin, empathy, hair, and cinnamon

in General 136 upvotes 4 months ago

Low oxytocin levels in hair are linked to reduced empathy and may affect hair growth. Cinnamic acid can promote hair growth by activating oxytocin receptors.

Related Research

5 / 5 results

research Sisaipho Alopecia Areata Treated With Tofacitinib and Oral Minoxidil

1 citations, August 2022 in “JAAD case reports”

Tofacitinib and oral minoxidil may help treat Sisaipho alopecia areata.

research Hair Disorders

August 2018 in “Oxford University Press eBooks”

The document's conclusion cannot be provided because the document cannot be parsed.

research Hair Loss (Alopecia or Baldness)

June 2018

Baldness is often hereditary and linked to male hormones, becoming noticeable when half the hair is lost.

research Is the Comb Over Dying? A Mouse Model for Male Pattern Baldness (Androgenic Alopecia)

3 citations, April 2010 in “Endocrinology”

The mouse model suggests male pattern baldness may be due to an enzyme increasing DHT and higher androgen receptor levels in hair follicles.

research Drugs Affecting Hair Growth

January 1990

Different hair growth phases affect how follicles respond to X-rays, and hormones like testosterone and dihydrotestosterone play a key role in baldness; transplanted hair can grow on bald scalp areas.