Transcriptomic Profiling of Frontal and Occipital Dermal Papilla Reveals Potential Role of TRPS1 in Androgenic Alopecia

July 2022 in “ Journal of Investigative Dermatology ”

Saurav Limbu, Nilofer Farjo, Bessam Farjo, Peter D. Kemp, Charles B. Higgins

TRPS1 androgenic alopecia dermal papilla frontal dermal papilla occipital dermal papilla keratin 75 androgen receptor hair follicle miniaturization anagen telogen AGA DP FDP ODP K75 AR

TLDR TRPS1 loss in balding scalp areas contributes to hair loss in androgenic alopecia.

The study investigates the role of TRPS1 in androgenic alopecia (AGA) by comparing dermal papilla (DP) cells from balding (frontal, FDP) and nonbalding (occipital, ODP) scalp regions. Using an in vitro double spheres assay, it was found that FDP cells induce a 1.23X reduction in the hair marker keratin 75 (K75) expression compared to ODP cells, indicating impaired BC differentiation ability in FDP. Transcriptomic analysis revealed a 1.7X upregulation of TRPS1 in ODP compared to FDP, which remained significant but reduced to 1.2X in cultured spheres. Knocking down TRPS1 in ODP resulted in a 1.1X reduction in K75 expression, suggesting TRPS1's role in DP signaling to BC. Activation of the androgen receptor (AR) in DP spheres led to a 2X decrease in TRPS1, implicating androgens in TRPS1 loss in FDP. The data supports that TRPS1 loss in FDP contributes to hair follicle miniaturization in AGA by impairing DP's signaling to BC during the anagen to telogen transition.

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