Corticotropin-Releasing Hormone Inhibits Autophagy by Suppressing PTEN to Promote Apoptosis in Dermal Papilla Cells

This study investigates the mechanisms behind stress-related hair loss, focusing on the role of corticotropin-releasing hormone (CRH) in dermal papilla cells (DPCs). It was found that CRH suppresses PTEN, leading to reduced autophagy and increased apoptosis in DPCs, which contributes to hair loss. The study utilized 4D label-free quantitative proteomics and a chronic unpredictable mild stress mouse model to explore these effects. Results showed that CRH activates the PI3K/AKT/mTOR pathway, inhibiting autophagy and promoting apoptosis. Conversely, overexpression of PTEN or the use of rapamycin, which inhibits the PI3K/AKT/mTOR pathway, enhanced autophagy and reduced apoptosis. These findings suggest that targeting PTEN activation or enhancing autophagy could be potential therapeutic strategies for treating stress-induced hair loss, such as alopecia.