TLDR KRT2.13 gene is similar to KRT2.9 but not expressed in hair follicles.
The study focused on the Intermediate Filament (IF) superfamily, particularly the keratin families, which were the largest within this group. Researchers sequenced a gene related to a previously studied hair IF type II keratin gene (KRT2.9) and identified it as encoding a hair-like IF type II protein (KRT2.13). Despite its classification, KRT2.13 was not expressed in the hair follicle. The study found significant sequence homology between certain introns of KRT2.13 and KRT2.9, suggesting possible gene conversion or conservation of functional sequences.
18 citations
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February 1992 in “Molecular Biology Reports” A specific type II hair keratin was identified and found in hair cortex and tongue cells.
65 citations
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February 1992 in “Development” Type II keratin genes are crucial for hair follicle differentiation and have a conserved structure and expression pattern.
98 citations
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December 1991 in “Annals of the New York Academy of Sciences” Keratin gene regulation is similar across mammals, affecting hair follicle differentiation.
21 citations
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December 1991 in “Annals of the New York Academy of Sciences” Most mouse hair keratin genes are on chromosomes 11 and 15.
49 citations
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October 1989 in “Genomics” Type I keratin genes are closely linked to the rex locus on mouse chromosome 11, affecting hair development.
128 citations
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March 1989 in “Experimental Cell Research” Hoxc13 is important for hair and tongue development by controlling hair keratin genes.
5 citations
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January 1988 Only two of the four keratin genes are expressed in wool fibers.
29 citations
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April 2003 in “Experimental dermatology” Human hair follicles grown in vitro maintain normal keratin patterns and structure.
