October 2025 in “The Sri Lanka Journal of Dermatology” This case report highlights the diagnostic challenge of inverted follicular keratosis, emphasizing the importance of histopathology for accurate differentiation from malignancies.
September 2024 in “Journal of the American Academy of Dermatology” In this case report, a 53-year-old woman with Little-Graham-Piccardi-Lassueur-Syndrome responded well to a treatment regimen of hydroxychloroquine, methotrexate, and other therapies, effectively halting the progression of this rare dermatosis characterized by alopecia and hyperkeratotic eruptions.
2 citations
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April 2024 in “Journal of Dermatological Science” This study suggests that the MLKL-targeting inhibitor Necrosulfonamide promotes hair growth and counteracts DHT inhibition by activating Wnt signaling in hair follicle cells, revealing potential avenues for anti-alopecia drug development.
13 citations
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March 2008 in “Journal of the European Academy of Dermatology and Venereology” This article reports a case of linear lichen planus developing along the lines of Blaschko during intramuscular triamcinolone acetonide therapy for alopecia areata multiplex.
169 citations
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May 2006 in “Genes & Development” This study found that keratin 17 and TNFα play interdependent roles in regulating hair follicle cycling, with TNFα required for the anagen–catagen transition and its ablation partially rescuing hair cycling defects in K17-null mice.
19 citations
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April 1999 in “British Journal of Dermatology” This study shows that keratin 2e exhibits distinct temporal and regional expression patterns in fetal epidermis, suggesting different regulatory and functional roles from other epidermal keratins.
April 2023 in “Journal of Investigative Dermatology” This study found that KROX20 is crucial for hair follicle development and epidermal homeostasis, as its deletion in skin epithelial cells led to hair loss and increased epidermal thickness.
May 2024 in “International journal of medicine and psychology.” This study examined monoclonal antibodies LT-1, LT-2, and LT-7, finding they can effectively detect certain antigens on T and B cells involved in various lymphoproliferative diseases, aiding in the diagnosis of both acute and chronic lymphoid neoplasias.
175 citations
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September 1998 in “British Journal of Dermatology” This study found that mutations in the K17 gene underlie both pachyonychia congenita type 2 and steatocystoma multiplex phenotypes, regardless of the specific mutation involved.
November 2024 in “Journal of Investigative Dermatology” This study identified PTEN as a key regulator in non-healing venous leg ulcers, suppressing immune responses and lymphangiogenesis, suggesting its potential as a therapeutic target for promoting VLU healing.
17 citations
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October 2006 in “Molecular and Cellular Endocrinology” This study found that the L457(3.43)R mutation in the human luteinizing hormone receptor increases phosphodiesterase activity, reducing hormonal response despite elevated basal cAMP levels.
September 2023 in “Journal of the American Academy of Dermatology” This study found that in participants with notalgia paresthetica, 8 weeks of treatment with difelikefalin significantly improved itch intensity and increased the rate of strict complete response compared to placebo, starting as early as week 3.
4 citations
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May 2024 in “Cytotechnology” September 2017 in “Journal of Investigative Dermatology” LRIG1 protein affects hair growth by regulating skin receptors, leading to hair loss when overexpressed.
104 citations
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July 1994 in “The Journal of Cell Biology” This study suggests that basonuclin in keratinocytes is likely a regulatory molecule linked to maintaining proliferative capacity and preventing terminal differentiation rather than a cell cycle marker.
January 2012 in “Human health handbooks” This review discusses the application of low-level light therapy for hair loss treatment, particularly androgenetic alopecia, and reports no new clinical results; the authors suggest consideration of light source characteristics and potential pros and cons.
This report describes a rare case of kerion in a 6-year-old boy in Ireland, treated with oral Itraconazole and steroids, highlighting the condition's unusual occurrence in the region.
September 2016 in “Journal of Dermatological Science” Polarizing light microscopy can easily and reliably diagnose congenital keratinizing disorders like Netherton syndrome.
February 2025 in “Journal of Clinical Investigation” This study found that RNase L acts as a regeneration repressor gene in mammals, as seen in Rnasel-/- mice which showed increased regenerative capacity and elevated Wound Induced Hair Neogenesis through enhanced IL-36α signaling, suggesting a tradeoff between regeneration and immune regulation.
22 citations
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April 2011 in “Anais Brasileiros de Dermatologia” This report describes two cases where lichen planopilaris may have compromised the hair follicles in both donor and recipient areas following follicular unit transplantation.
January 2024 in “Brazilian Journal of Hair Health” Combining low-level laser therapy with topical corticosteroids effectively improved Lichen Planopilaris symptoms.
5 citations
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November 2005 This review discusses the applications of confocal laser scanning microscopy in visualizing fluorescent compounds within the skin, noting its potential for tracking drug carriers and enhancing penetration studies, but reports no new results.
March 2025 in “International Journal of Molecular Sciences” This study established a Krt24-CreERT2 mouse line targeting outer bulge hair follicle stem cells, finding these cells crucial for hair follicle development and repair, particularly following ionizing radiation exposure.
This report describes a case where a young woman developed Kerion Celsi, a fungal skin infection, potentially linked to the use of a tretinoin, minoxidil, and betamethasone valerate lotion.
40 citations
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September 2010 in “Journal of Biological Chemistry” This study found that keratin K80, structurally similar to hair keratins, is broadly expressed in various epithelial tissues and is involved in intermediate filament formation with multiple type I partners.
2 citations
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January 2022 in “Indian dermatology online journal” This case report details the dermoscopic features of bilateral cutaneous larva migrans in an adult male, noting similarities with lymphangioma circumscriptum but highlights that typical dermoscopy magnification may be insufficient for diagnosis.
8 citations
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November 2022 in “Cureus” In this study, patients with mild to moderate scalp seborrheic dermatitis experienced greater improvements in severity scores and quality of life with Lulican™ shampoo compared to Ketoconazole over four weeks, with similar safety profiles but better tolerability and cosmetic acceptability for LulicanTM.
January 2022 in “Revista Dermatológica Centro Uraga” This article reviews two cases of monilethrix in siblings, detailing their clinical and dermatoscopic characteristics, but reports no new findings.
September 2022 in “JAAD case reports” This case study of a 45-year-old man from Tonga describes the identification of pachyonychia congenita through genetic testing, revealing a mutation in the keratin gene KRT16, associated with chronic painful skin and nail conditions.
December 2025 in “Medical Lasers” This prospective study found that 1,927-nm fractionated thulium laser treatment significantly increased hair and terminal hair counts in 11 men with pattern hair loss, although it did not change average hair thickness, suggesting it may be a promising therapy for this condition.