Patchy Hair Loss, Hyperpigmented Plaques, and Hyperkeratotic Papules in a Middle-Aged Woman
September 2024
in “
Journal of the American Academy of Dermatology
”
Studysummary In this case report, a 53-year-old woman with Little-Graham-Piccardi-Lassueur-Syndrome responded well to a treatment regimen of hydroxychloroquine, methotrexate, and other therapies, effectively halting the progression of this rare dermatosis characterized by alopecia and hyperkeratotic eruptions. Our plain-language summary of this paper — not a Tressless recommendation.
Little-Graham-Piccardi-Lassueur-Syndrome (LGPLS) is a rare condition characterized by cicatricial alopecia of the scalp, non-scarring alopecia of the axillae and perineum, and hyperkeratotic follicular eruptions. A 53-year-old woman presented with symptoms consistent with LGPLS, including severe pruritus, progressive hair loss, and erythematous plaques. Examination and trichoscopy confirmed the diagnosis, revealing irregular alopecic areas and follicular plugging. Histopathology showed a lichenoid infiltrate, confirming lichen planus and lichen planopilaris. Treatment included oral prednisone, topical clobetasol, hydroxychloroquine, methotrexate, folic acid, topical tacrolimus, and minoxidil. The patient responded well to treatment, with no progression of the dermatosis.
