Patchy Hair Loss, Hyperpigmented Plaques, and Hyperkeratotic Papules in a Middle-Aged Woman

    September 2024 in “ Journal of the American Academy of Dermatology ”
    Marco Zúñiga, Perla Calderón, Debanhi Kassandra Luna Garza, A. Herrera, Jorge Ocampo‐Candiani, Sonia Sofia Ocampo Garza
    Image of study
    TLDR The patient responded well to treatment with no disease progression.
    Little-Graham-Piccardi-Lassueur-Syndrome (LGPLS) is a rare condition characterized by cicatricial alopecia of the scalp, non-scarring alopecia of the axillae and perineum, and hyperkeratotic follicular eruptions. A 53-year-old woman presented with symptoms consistent with LGPLS, including severe pruritus, progressive hair loss, and erythematous plaques. Examination and trichoscopy confirmed the diagnosis, revealing irregular alopecic areas and follicular plugging. Histopathology showed a lichenoid infiltrate, confirming lichen planus and lichen planopilaris. Treatment included oral prednisone, topical clobetasol, hydroxychloroquine, methotrexate, folic acid, topical tacrolimus, and minoxidil. The patient responded well to treatment, with no progression of the dermatosis.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 58 results

      community Duta 2,5mg/day - No Progress - 28M

      in Update  5 upvotes 2 weeks ago
      A 28-year-old is experiencing hair loss despite using treatments like oral minoxidil, finasteride, and high-dose dutasteride (2.5 mg). They suspect lichen planus might be contributing to the issue and plan to continue treatment while monitoring progress.
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 8 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community He used Dutasteride for 20 years. Interview

      in Treatment  112 upvotes 5 months ago
      Dutasteride has been used for 20 years with some hair thickness improvement but no dramatic regrowth. The user also experimented with minoxidil, tretinoin, and peptides like BPC 157 for potential benefits in hair density and quality.

      community Clascoterone (Winlevi) Update for Canada

      in Treatment  17 upvotes 2 years ago
      Clascoterone cream was submitted for review to Health Canada in August 2022, with hopes of approval within 3-6 months. It may potentially enhance finasteride's effects for hair loss treatment.

      community I've tried everything and my hair is still thinning

      in Chat  6 upvotes 1 year ago
      The user has tried finasteride, oral minoxidil, iron supplements, vitamin D, and vitamin B12, but their hair is still thinning after 5 years. Another user suggested trying dutasteride.

      community Pili migrans? Lichen something? Seb derm?

      in Female  19 upvotes 2 weeks ago
      The conversation is about a female experiencing hair loss and seeking advice on why it's difficult to regrow hair. Specific treatments like Minoxidil, finasteride, or RU58841 are not mentioned.

    Similar Research

    5 / 1000+ results