TLDR The patient responded well to treatment with no disease progression.
Little-Graham-Piccardi-Lassueur-Syndrome (LGPLS) is a rare condition characterized by cicatricial alopecia of the scalp, non-scarring alopecia of the axillae and perineum, and hyperkeratotic follicular eruptions. A 53-year-old woman presented with symptoms consistent with LGPLS, including severe pruritus, progressive hair loss, and erythematous plaques. Examination and trichoscopy confirmed the diagnosis, revealing irregular alopecic areas and follicular plugging. Histopathology showed a lichenoid infiltrate, confirming lichen planus and lichen planopilaris. Treatment included oral prednisone, topical clobetasol, hydroxychloroquine, methotrexate, folic acid, topical tacrolimus, and minoxidil. The patient responded well to treatment, with no progression of the dermatosis.
8 citations,
October 2018 in “Journal of The American Academy of Dermatology” The review suggests there's no agreed treatment for Frontal Fibrosing Alopecia, but hydroxychloroquine and 5a-reductase inhibitors are most effective. New treatments like platelet-rich plasma and LED light could help if standard treatments fail.
117 citations,
March 2013 in “Journal of the European Academy of Dermatology and Venereology” No effective treatment for frontal fibrosing alopecia was found, but oral 5-alpha-reductase inhibitors had the best response; for lichen planopilaris, topical corticosteroids were commonly used but had a high relapse rate.
August 2022 in “IntechOpen eBooks” The best treatment for Frontal Fibrosing Alopecia and Lichen Planopilaris combines oral and topical medications to reduce symptoms and stop hair loss.
17 citations,
October 2017 in “Journal of Cutaneous Medicine and Surgery” No treatment has been proven to effectively stop hair loss or regrow hair in Frontal Fibrosing Alopecia, and more research is needed.
155 citations,
June 2009 in “International Journal of Dermatology” Lichen planus is a skin condition that can resolve on its own, is linked to hepatitis C, and increases the risk of skin cancer.
