research Whole Exome Sequencing in Alopecia Areata Patients Identifies a Hotspot Mutation in the Type II Hair Keratin Gene, KRT82
A mutation in the KRT82 gene is significantly associated with Alopecia Areata.
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research Efficacy and Safety of L-Cystine Associated or Not to a Natural Keratin (Kera-Diet) Hydrolysate on Hair and Nails: Randomized, Placebo-Controlled, Clinical Trial on Healthy Females
L-Cystine and L-Cystine with Kera-Diet® safely improved hair and nail quality in healthy women.
research A Dermoscopic Clue for the Diagnosis of Traction Alopecia: Peripilar Keratin Casts Case Report
Peripilar keratin casts are a helpful sign for diagnosing traction alopecia.
research Effect of Anti-Keratin Antibody on the Nature of Hair
Anti-keratin antibody from cow milk makes damaged hair stronger and less likely to break.
research Bidirectional Binding Property of High Glycine–Tyrosine Keratin-Associated Protein Contributes to the Mechanical Strength and Shape of Hair
High glycine–tyrosine keratin-associated proteins help make hair strong and maintain its shape.
research Characterization and Chromosomal Localization of Human Hair-Specific Keratin Genes and Comparative Expression During the Hair Growth Cycle
Two specific hair keratin genes are active during hair growth and decline as hair transitions to rest.
research Human Hair Keratin-Based Hydrogels in Regenerative Medicine: Current Status and Future Directions
Human hair keratin hydrogels show promise for use in regenerative medicine.
research Differential expression of keratin and keratin associated proteins are linked with hair loss condition in spontaneously mutated inbred mice
research Downregulation of mRNAs Encoding Keratin-Associated Proteins in the Tongue of Mice Fed a High-Fat Diet
A high-fat diet may weaken tongue structure by reducing certain protein genes.
research Investigation of Human Hair Keratin-Based Nanofibrous Scaffold for Skin Tissue Engineering Application
Human hair keratin was used to create a scaffold that could help with skin repair.
research Author Correction: Keratin-Mediated Hair Growth and Its Underlying Biological Mechanism
research Publisher Correction: Keratin-Mediated Hair Growth and Its Underlying Biological Mechanism
research Mutation Analysis of the Type II Hair Keratin Gene in a Family of Han Nationality with Monilethrix
A specific gene mutation causes monilethrix in this family, and minoxidil treatment improves hair condition.
research Human Hair Keratin Protein, Hair Fibers and Hydroxyapatite (HA) Composite Scaffold for Bone Tissue Regeneration
research Chronological ageing of human hair keratin fibres
research Ovine KRTAP36-2: A New Keratin-Associated Protein Gene Related to Variation in Wool Yield
The KRTAP36-2 gene in sheep affects wool yield.
research Epidermal Abnormalities and Increased Malignancy of Skin Tumors in Human Epidermal Keratin 8-Expressing Transgenic Mice
Mice with human skin protein K8 had more skin problems and cancer.
research Establishment of Individuality and Determination of Inheritance from Hair Keratin Phenotypes in North Indian Population
research Conditional Gene Expression in the Epidermis of Transgenic Mice Using the Tetracycline-Regulated Transactivators tTA and rTA Linked to the Keratin 5 Promoter
The study demonstrated the use of tetracycline-regulated transactivators (tTA and rTA) linked to the keratin 5 promoter to achieve conditional gene expression in the epidermis of transgenic mice. By modulating doxycycline levels, researchers could control β-galactosidase activity, with significant increases observed in the epidermis, particularly in hair follicles and the basal layer. The K5/tTA line showed a 500-fold increase in enzyme activity without doxycycline, while K5/rTA lines exhibited a 3- to 50-fold increase with doxycycline induction. This system allowed for precise temporal and quantitative control of gene expression, proving useful for studying epidermal biology, including growth control, differentiation, carcinogenesis, and wound healing. The findings suggested that the K5 promoter might be more effective than the CMV promoter for maintaining expression in keratinocytes.
research Unique Amino Acid Signatures That Are Evolutionarily Conserved Distinguish Simple-Type, Epidermal, and Hair Keratins
Different keratin types have unique amino acid patterns that are evolutionarily conserved.
research Beyond Expectations: The Role of Keratin Intermediate Filament Proteins in Epidermal Integrity
Keratin proteins are crucial for healthy skin, but mutations can cause skin disorders with no effective treatments yet.
research Keratins and Skin Disease: Genetic and Molecular Roles
Keratin mutations cause skin diseases and could lead to new treatments.
research The Keratins and Their Disorders
Mutations in keratin genes cause cell fragility and various skin disorders.
research Structure–Property Relationships of Meta-Kerateine Biomaterials Derived from Human Hair
Protein composition greatly affects the function of keratin biomaterials.
research Keratin and Skin Disorders
Changes in keratin affect skin health and can lead to skin disorders like blistering diseases and psoriasis.
research The Proteomic Profile of Hair Damage
Bleaching hair damages protein structure, especially keratin, leading to weakened hair.
research Hair Follicle Transcriptome Profiles During the Transition from Anagen to Catagen in Cashmere Goat (Capra Hircus)
The transition from growth to regression in Cashmere goat hair follicles involves changes in expression of genes related to keratin and cell differentiation.
research Keratins: Dynamic, Flexible Structural Proteins of Epithelial Cells
Keratin proteins in epithelial cells are dynamic and crucial for cell processes and disease understanding.
research Homo- and Heteropolymer Self-Assembly of Recombinant Trichocytic Keratins
Recombinant keratins can form useful structures for medical applications, overcoming natural keratin limitations.
research Electrophoretic Variability in Human Hair: Comparative Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis of Body and Head Hair Proteins
Keratin proteins are consistent across different hair types from the same person.