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TGF-β1 from dermal papilla cells suppresses hair growth, and targeting it may help treat androgenetic alopecia.

This study suggests genetic and clinical heterogeneity in keratosis pilaris atrophicans, with variations in inheritance patterns, severity, and response to treatment among 21 individuals observed.

This study found that TRPV3 ion channels on human epidermal keratinocytes suppress cell proliferation, induce cell death, and trigger a proinflammatory response, suggesting a role in cutaneous inflammatory processes.

This study found that the enzyme A20 helps regulate EDAR-induced NF-κB signaling in mice, preventing ectodermal abnormalities like disheveled hair and assuring proper skin and appendage development.

This study found that keratins have evolutionarily conserved and domain-selectively enriched amino acids, which likely reflect their unique structural roles, with distinct patterns observed among epidermal, hair, and simple-type epithelial keratins.

This research observed that sheep and rabbit KAP6 genes, expressed in hair follicle cells, have high sequence similarity and indicate conservation due to evolutionary selection pressures.

This study found that alkylation of kerateine cysteine residues created a cell-compatible method for controlling hydrogel erosion rates and therapeutic agent release in keratin-based systems.

In this study, specific genetic polymorphisms in the KRT71 gene were associated with hairless and curly phenotypes in Sphynx and Devon Rex cats.

This study suggests that mouse keratin 6 isoforms, K6a and K6b, have overlapping but distinct expression profiles, differing notably in their expression in suprabasal cells and response to phorbol esters.

This study found that Hopx labels a long-lived progenitor population in hair follicles, which contributes to hair follicle stem cell homeostasis and has an alternative origin from previously thought progenitors.

This study found that PKCα activation in transgenic mice induces keratinocyte apoptosis and mediates neutrophilic skin inflammation via different pathways, suggesting potential mechanisms for cutaneous inflammatory diseases.

This study found that hair depigmentation in mice and humans can be a dynamic indicator of KIT inhibition by the drug SU11248, correlating with treatment periods.

Cornification evolved from keratinization in vertebrates, with differences between mammals and sauropsids.

This study found that the vitamin D-VDR system is crucial for mineral and bone metabolism post-weaning and identified missense mutations in 1alpha-hydroxylase causing type I rickets.

This study found that the differential expression of α- and β-keratin genes in feathers may explain their morphological and structural diversity, highlighting the chicken as a model for studying keratin-related diseases.

This study provides genetic evidence that desmoglein-1 can compensate for the loss of desmoglein-3 in hair adhesion, supporting the desmoglein compensation hypothesis.

Minoxidil helps hair cells live longer and grow longer.

This study found that zinc is primarily located in the tails of mature rat sperm, associated with -S-S-bonded structures, and suggests a possible similarity in zinc interactions between sperm keratin and hair proteins.

This study revealed that human keratin-associated protein genes are expressed in specific patterns in hair fiber regions and vary in size, with some variations distinct across different populations.

Keratin-based hydrogels from human hair and wool are promising for wound dressings and are more eco-friendly.

This study explored the interaction between androgen and Wnt signaling in dermal papilla cells, targeting the effects of androgen on hair growth reduction.

K39 and K40 are the last keratins expressed in hair development, completing the hair keratin catalog.

This study identifies six novel keratin genes from the chromosome 17q21.2 region, suggesting their association with hair follicles, while all 27 keratin genes in the domain have been characterized transcriptionally.

This study found that permanent waving treatment partially disrupts the α-helical structure in human hair microfibrils, primarily during the initial reduction phase, rather than just affecting disulphide bonds.

This study found that activating CXCR2 on ras-transformed keratinocytes promotes migration and tumor development in a mouse skin model.

Keratin mutations cause skin diseases and could lead to new treatments.

This study found that using a keratin hydrogel scaffold as a filler in collagen nerve conduits significantly improved nerve regeneration and motor recovery in Macaca fascicularis monkeys compared to saline.

This study found that the angora mouse mutation prolongs the anagen phase, resulting in excessively long hair and follicular abnormalities, without involving circulating hair cycle factors.

This study found that keratin genes in the epidermis of aquatic mammals like cetaceans have evolved to replace stress-inducible keratins K1 and K10 with constitutively expressed K6 and K17, suggesting adaptations to their environment.