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210-240 / 1000+ resultsresearch Emerging Topical and Systemic JAK Inhibitors in Dermatology
This review discusses the immunological basis and development of Janus kinase inhibitors for treating skin diseases and reports no new clinical findings.
research 891 Comparison of phenotypes and transcriptomes of mouse skin-derived precursors and dermal mesenchymal stem cells
This study reported that mSKPs and DMSCs share similarities in biological characteristics but exhibit distinct transcriptome profiles, with mSKPs being more immune-related and DMSCs more associated with differentiation and disease pathways.
research 576 A preliminary study of melanogenic markers in the differentiation of the human hair follicle melanin unit
This study found that early pigment cell markers Sox10 and c-KIT, as well as DCT/TRP-2, were detectable in melanogenically-active melanocytes of the anagen bulb in human hair follicles.
research Artificial Intelligence as the New Backbone of Aesthetic Practice in India: A Comprehensive, Fully Referenced Industry Whitepaper
In this study, artificial intelligence's integration into Indian aesthetic medicine has expanded from consumer apps to crucial roles in diagnostics, treatment planning, and clinic management, driven by demands for precise data over subjective opinions and enhancing competitive advantage.
research Innovative Therapeutic Strategies in TYK2-Targeted Treatments: From Cancer to Autoimmune Disorders
This Patent Highlight discusses recent progress in developing TYK2 inhibitors, which show potential for treating conditions like cancer, alopecia areata, and psoriatic arthritis.
research Efficacy and safety of ritlecitinib, an oral JAK3/TEC family kinase inhibitor, in adolescent and adult patients with alopecia totalis and alopecia universalis
This study evaluated the effectiveness and safety of ritlecitinib in patients aged 12 or older with alopecia totalis or universalis, finding higher hair regrowth response rates compared to placebo at 24 weeks, with continued improvement and acceptable safety through 48 weeks.
research K15 promoter-driven enforced expression of NKIRAS exhibits tumor suppressive activity against the development of DMBA/TPA-induced skin tumors
This study found that NKIRAS2 expression affects skin tumor suppression and HRAS-driven transformation in mice, indicating its role in carcinogenesis depends on expression level and cellular context.
research P-13 Some biomechanical properties of human hair keratin (HHK) artificial tendon
research Transgenic Kallikrein 14 Mice Display Major Hair Shaft Defects Associated with Desmoglein 3 and 4 Degradation, Abnormal Epidermal Differentiation, and IL-36 Signature
This study identifies KLK14 as a significant factor contributing to hair defects and skin inflammation in a mouse model of Netherton syndrome.
research Correction of Tear Trough Deformity Using Autologous Fibroblast Combined with Keratin: New Soft Tissue Filler
In this study, autologous fibroblasts combined with keratin gel were reported to effectively and safely improve tear trough deformities up to 24 months post-injection, with no severe adverse effects observed.
research DKK1 Mediated Inhibition of Wnt Signaling in Postnatal Mice Leads to Loss of TEC Progenitors and Thymic Degeneration
This study demonstrates that canonical Wnt signaling is crucial for maintaining thymic epithelial microenvironments in postnatal thymus, possibly by affecting TEC progenitor cells.
research Nematic Fibrin Fibers Enabling Vascularized Thrombus Implants Facilitate Scarless Cutaneous Wound Healing
In this study, implantable vascularized engineered thrombi using autologous whole blood improved skin wound healing in rats by promoting robust microcapillary networks and accelerating healing processes.
research SYK inhibitor entospletinib prevents ocular and skin GVHD in mice
In a preclinical mouse model, this study found that early treatment with the selective SYK inhibitor entospletinib significantly improved survival rates and clinical outcomes for graft-versus-host disease after hematopoietic stem cell transplantation compared to placebo.
research Expression patterns of keratin intermediate filament and keratin associated protein genes in wool follicles
Gene expression in wool follicles changes with growth cycles, offering insights into wool and human hair growth.
research Trichotillomania Incognita in an Adult Female: A Great Mimicker Worth Attention!
This study reports a unique case of trichotillomania incognita in an adult female that mimicked female pattern hair loss, highlighting the importance of trichoscopy and histology for accurate diagnosis.
research Immunohistochemical localization of tgf-β in alopecia areata
research Decision letter: Intercellular propagation of extracellular signal-regulated kinase activation revealed by in vivo imaging of mouse skin
This study found that bursts of ERK activation in the epidermis of mice were linked to cell division, supporting synchronized cell proliferation and transient ERK activity in living tissues.
research Immunohistochemical expression of cytokeratin 15, cytokeratin 19, follistatin, and Bmi-1 in basal cell carcinoma
This study suggests that basal cell carcinoma and trichoblastoma may share differentiation toward the hair follicle, as indicated by strong positivity in CK 15, follistatin, and Bmi‐1 markers.
research Ex vivo SIM-AFM measurements reveal the spatial correlation of stiffness and molecular distributions in 3D living tissue
This study introduced a novel method that uses upright structured illumination microscopy and atomic force microscopy to map the mechanical properties of thick living tissue slices, revealing the intricate mechanical heterogeneity of mouse skin and effects of preservation techniques on tissue stiffness.
research Temporal triangular alopecia: Trichoscopic diagnosis
This article discusses the trichoscopic diagnosis of temporal triangular alopecia, but reports no new clinical results.
research In vitro and in vivo study of dye diffusion into the human skin and hair follicles
This study found that commercially available dyes penetrate up to 1.2 mm into human skin, with Indocyanine Green binding to cell proteins and showing a shift in absorption peak.
research A comparative study of materials assembled from recombinant K31 and K81 and extracted human hair keratins
This study found that recombinant human hair keratin proteins K31 and K81 show greater potential for inducing skin cell differentiation compared to natural keratin coatings.
research A Combinatorial Tweet Clustering Methodology Utilizing Inter and Intra Cosine Similarity
This thesis presents research conducted in partial fulfillment of a Master's degree in Software Systems Engineering but does not report new empirical findings.
research [An immunohistochemical study on the normal human anagen hair and hair follicle using anti-hair keratin monoclonal antibodies (HKN-5, HKN-6, HKN-7 and HKN-8)].
research KEBOT: An Artificial Intelligence Based Comprehensive Analysis System for FUE Based Hair Transplantation
This study reports that a robotic and AI-based system successfully analyzes FUE hair transplant procedures, aiding surgeons in planning and assessing operation success through detailed pre-op and post-op evaluations.
research Tibial cortex transverse transport accelerates diabetic wound healing via systemic mobilization of non-classical monocytes
In this study, tibial cortex transverse transport accelerated wound healing in diabetic rats, potentially through enhanced mobilization of non-classical monocytes and increased M2 macrophage polarization.
research Targeting the Janus Kinase Family in Autoimmune Skin Diseases
This review discusses the role of the JAK-STAT pathway in autoimmune skin diseases and suggests potential therapeutic benefits of JAK inhibitors, but reports no new experimental results.
research Immunohistochemical analysis of tissue remodelling during the anagen-catagen transition of the human hair follicle
This research observed that during the catagen phase, the inner root sheath of hair follicles becomes an early target, highlighting its potential role in maintaining hair follicle homeostasis.
research Mutations in the helix termination motif of mouse type I IRS keratin genes impair the assembly of keratin intermediate filament
This study found that mutations in type I IRS keratin genes disrupt keratin protein complexes in mice, suggesting crucial roles for these genes in proper hair coat formation.