6 citations,
April 2014 in “European journal of medicinal chemistry” New compounds similar to cromakalim were less effective at inhibiting insulin release but improved in solubility and one acted as a calcium entry blocker, not a potassium channel opener.
2 citations,
January 2019 in “Egyptian Journal of Dermatology and Venereology” Insulin might be involved in causing hair loss and acne.
1 citations,
January 2022 in “Journal of experimental and clinical medicine” PCOS is linked to diabetes and insulin resistance, and managing AGEs may help treat related symptoms.
February 2024 in “Bioengineering” The hydrogel made of chitosan, HPMC, and insulin speeds up wound healing and could be a new dressing, especially for diabetics.
August 2015 in “Postgraduate obstetrics & gynecology” Women with PCOS often have insulin resistance, abnormal lipid levels, and a higher risk of diabetes and heart disease; lifestyle changes and medication like metformin can help manage these risks.
August 2015 in “Postgraduate obstetrics & gynecology” Women with PCOS often have metabolic issues like insulin resistance and a higher risk of diabetes and abnormal lipid levels.
The conclusion is that there's a link between high testosterone levels, insulin resistance, and certain skin conditions, regardless of obesity.
February 2023 in “Clinical, Cosmetic and Investigational Dermatology” Higher leptin and lower vitamin D levels may contribute to male pattern baldness.
March 2022 in “Benha Journal of Applied Sciences” AGA patients have higher insulin resistance and serum progranulin levels, suggesting a link to metabolic issues.
343 citations,
December 2008 in “Endocrine Reviews” Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.
258 citations,
July 2016 in “Reproductive Biology and Endocrinology” The document concludes that insulin resistance is key in PCOS development and early treatment is crucial to prevent complications.
200 citations,
October 2009 in “European journal of endocrinology” Metformin helps manage polycystic ovary syndrome by improving insulin resistance and ovulation, but more research is needed on its full effects.
198 citations,
July 2011 in “Cochrane library” Lifestyle changes can improve body composition, excess male hormone levels, and insulin resistance in women with PCOS.
128 citations,
December 2006 in “Journal of Biological Chemistry” Altering SSAT affects fat metabolism and body fat in mice.
114 citations,
January 2014 in “World Journal of Gastroenterology” People with PCOS, especially if obese, often have NAFLD, linked to obesity, insulin resistance, and high androgen levels.
60 citations,
February 2010 in “Gynecological Endocrinology” Metformin combined with lifestyle changes improves insulin resistance and reduces testosterone levels in women with PCOS more than lifestyle changes alone.
56 citations,
July 2008 in “European journal of endocrinology” Metformin and rosiglitazone improve blood vessel function in women with PCOS, with metformin also reducing insulin resistance and testosterone levels.
53 citations,
December 2015 in “JAMA Dermatology” Women with PCOS often have more body hair, acne, and skin darkening, and these signs are linked to metabolic issues like insulin resistance and high cholesterol.
40 citations,
April 2008 in “European journal of endocrinology” Metformin and rosiglitazone both improved insulin use and hormonal symptoms in women with PCOS.
31 citations,
January 2014 in “Clinical Endocrinology” The study suggests that being overweight or obese, not PCOS itself, is strongly linked to insulin resistance.
30 citations,
September 2017 in “Clinics in Dermatology” Acanthosis nigricans is a skin condition that may indicate a higher risk for insulin resistance and type 2 diabetes, and more research is needed to understand and treat it.
20 citations,
October 2017 in “Clinical Endocrinology” The conclusion is that removing both ovaries is the best treatment for excess male hormones in postmenopausal women, with medication as another option, and managing insulin resistance is important for diagnosis and treatment.
20 citations,
March 2017 in “Reproductive Biology and Endocrinology” Women with PCOS have higher 5α-reductase activity, which may be linked to insulin resistance.
18 citations,
February 2010 in “Odontology” The document concludes that Rabson-Mendenhall syndrome requires novel treatments for insulin resistance and emphasizes the importance of dental care in affected patients.
17 citations,
May 2014 in “Cell transplantation” Genetically modified stem cells from human hair follicles can lower blood sugar and increase survival in diabetic mice.
14 citations,
September 2017 in “Clinics in Dermatology” Skin diseases linked to insulin resistance should be managed to prevent diabetes and reduce heart disease risk.
14 citations,
March 2010 in “Gynecological endocrinology” New treatments for excessive hair growth in women include insulin modulators and enzyme inhibitors.
12 citations,
April 2019 in “Scientific Reports” A protein called HMGB1 helps hair grow by affecting prostaglandin metabolism.
12 citations,
January 2004 in “Reproductive biomedicine online” Low-dose anti-androgen drugs and certain drug combinations are effective for hirsutism, and insulin sensitizers show promise, especially for those with polycystic ovarian syndrome.
10 citations,
January 2019 in “Indian Journal of Dermatology” Early-onset male hair loss is linked to metabolic syndrome, suggesting a need for heart health monitoring and lifestyle changes.