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Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.

A specific gene change plus an additional mutation in the same gene cause hereditary trichilemmal cysts.

The type 3 IP3 receptor is important for controlling hair loss and growth.

Electro-acupuncture may help treat PCOS in rats by changing brain DNA methylation.

Estrogen increases blood vessel growth factor production, while testosterone blocks this increase.

lncRNAs may regulate hair follicle development in Hu sheep.

Overexpressing Tβ4 in goats' hair follicles increases cashmere production and hair follicle growth.

New patents show progress in developing drugs targeting the Wnt pathway for diseases like cancer and hair loss.

Wnt activation shows promise for regenerative medicine but requires selective targeting to minimize risks like cancer.

Neurotrophin-4 increases calcium current in specific mouse neurons through the PI3K pathway.

PCOS is a long-term condition that needs more research for better understanding and treatment.

Active oxygen species might be involved in skin tumor growth, but their exact role is unclear.

The skin acts like an endocrine organ, making hormones that affect skin diseases and respond to stress.

N-acetyl-L-cysteine (NAC) can prevent DNA damage and protect cells from harm.

The research linked PLCD1 gene variants to the development of trichilemmal cysts.

Genetic defects in testosterone production can cause hormonal and developmental disorders, and more research is needed to understand androgen regulation and develop safer treatments.

New treatments targeting T-cell pathways are needed for better alopecia areata management.

Oregano extract helps fix testis and sperm damage caused by finasteride.

Researchers created a model to understand heart aging, highlighting the role of microRNAs and identifying key genes and pathways involved.

Gray hair can potentially be reversed, leading to new treatments.

The document concludes that sex hormones are crucial for mammalian reproduction, health, and behavior, and require more research for therapeutic use.

NF-κB signaling is crucial in many diseases and can be targeted for new treatments.

Kir6.1 mutations in Cantú syndrome increase channel sensitivity and hyperpolarization, while SUR2B mutations do not.

Polycystic Ovary Syndrome (PCOS) is a hormonal disorder in women that can cause infertility and other health issues, and it may be improved by treatments that increase insulin sensitivity.

Researchers created a model to understand heart aging, highlighting key genes and pathways, and suggesting miR-208a as a potential heart attack biomarker.

Women with idiopathic hirsutism and PCOS have higher RBP4 levels, and PCOS is linked to greater insulin resistance; weight management may help both conditions.

Early treatment of PCOS in teens is crucial to prevent long-term health issues like diabetes and heart disease.

Young women in West Bengal, India, with PCOS often have estrogen resistance, leptin receptor issues, folate deficiency, T2DM, and acanthosis, commonly linked to obesity.

Lack of Cisd2 disrupts calcium balance in cells, leading to poorly functioning neutrophils.

Different light affects cell functions and can help treat skin conditions.