November 2022 in “Journal of Investigative Dermatology” This pilot study suggests that lovastatin may counteract stress-induced MICA expression in hair follicles and enhance MICA shedding, potentially offering a complementary approach for alopecia areata treatment.
1 citations
,
January 1987 This study found that low-output laser irradiation demonstrates biostimulatory effects on several biological systems and processes, including hair growth, wound healing, and immune function, with effects influenced by dose and exhibiting both stimulatory and inhibitory potential.
9 citations
,
September 2009 in “PubMed” This case report presents the first evidence of significant antigen presenting cells around hair follicles in a patient with alopecia due to active systemic lupus erythematosus.
February 2024 in “The Open dermatology journal” This systematic review reported that alopecia areata significantly impacts quality of life due to its psychological burdens, such as anxiety and depression, while emphasizing the need for increased awareness and support for affected individuals.
110 citations
,
December 2013 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” This article reviews current understanding of alopecia areata, its genetic and immune factors, and discusses ongoing research and treatment development, without presenting new experimental results.
7 citations
,
July 2013 in “InTech eBooks” This article describes the various presentations of oral lichen planus and notes it often requires topical or systemic immunosuppressive treatment for associated discomfort, but it reports no new clinical results.
6 citations
,
June 2023 in “Journal of the European Academy of Dermatology and Venereology” This study observed that inflammatory AIGA is associated with sweat duct inflammation and sweat coil atrophy, while non-inflammatory AIGA involves only sweat coil atrophy, suggesting distinct pathological features between the two.
5 citations
,
October 2012 in “Veterinary Pathology” This case study describes a Doberman Pinscher with a unique alopecic variant of chronic cutaneous lupus erythematosus that progressed to systemic lupus erythematosus, highlighting a rare autoimmune alopecia form in dogs.
4 citations
,
October 2022 in “Genes” This review discusses the role of cutaneous and intestinal microbiota in the development of alopecia areata, summarizing current literature without reporting new clinical results.
4 citations
,
April 2004 in “Medical veritas” This journal serves as a platform for diverse perspectives on vaccine-related issues, but the abstract itself reports no new scientific findings.
3 citations
,
February 2022 in “Rheumatology” In this report, a 25-year-old female patient with anti-MDA5 antibody-positive dermatomyositis and alopecia areata achieved complete remission of hair loss after treatment with baricitinib.
January 2022 in “Skin Appendage Disorders” This case report describes areata-like lupus in a 63-year-old woman, characterized by nonscarring patchy alopecia similar to alopecia areata, without meeting systemic lupus erythematosus criteria.
117 citations
,
September 2003 in “Molecular & cellular proteomics” This study demonstrated the development of high-density protein microarrays allowing for antibody binding characterization and serum profiling from patients with autoimmune diseases, suggesting potential for diagnostic marker discovery.
113 citations
,
June 2019 in “F1000Research” This review discusses the mechanisms of wound healing and excessive scarring, highlighting the importance of understanding these processes for developing new therapies to prevent fibrotic scarring in large skin wounds.
26 citations
,
April 2024 in “Particle and Fibre Toxicology” In this study, researchers investigated the penetration and cellular responses to nanoplastics in human skin models with compromised barriers, finding that nanoplastics can penetrate the skin, accumulate in cells, and trigger inflammatory responses through specific signaling pathways.
12 citations
,
November 2024 in “Burns & Trauma” This review highlights the critical role of neuroregulation in skin wound healing, emphasizing how neurotransmitters and neuropeptides regulate inflammation, angiogenesis, and cell proliferation, and discusses potential therapeutic strategies, such as neuromodulation, to enhance these processes.
February 2026 in “Exploration” This review summarizes research on scar formation and inhibition mechanisms, discussing emerging therapies like gene therapy and stem cell treatments, but notes ongoing challenges for clinical application, including treatment personalization and outcome sustainability.
April 2024 in “Military Medical Research/Military medical research” This review explores the current and experimental therapies for chronic wounds, emphasizing the potential of cellular and immunotherapies in addressing these persistent conditions, but notes a shortage of comprehensive studies on their effectiveness.
May 2018 in “International journal of cell science & molecular biology” This article discusses the biology of cosmetic aging and the chemical pathways involved, emphasizing research advancements that aid clinicians in rejuvenating skin and increasing scalp hair density, but it provides no new results.
This review highlights that alopecia areata is influenced by genetic, autoimmune, and environmental factors, with emerging treatments like JAK-2 inhibitors showing promise for severe cases.
45 citations
,
May 2024 in “International Journal of Molecular Sciences” This manuscript reviews the latest understanding of alopecia areata's pathogenesis, highlighting the roles of genetic, immunological, and environmental factors, with a focus on immune responses involving IFN-γ and cytotoxic CD8+ T-cells as key contributors to hair follicle inflammation and function disruption without follicle destruction.
6 citations
,
January 2015 in “Journal of regenerative medicine & tissue engineering” This review discusses the role of stem cells and tissue engineering in regeneration and transplantation, emphasizing the need for advanced technologies to improve treatments for injuries and disabilities, but reports no new results.
February 2026 in “Stem Cell Research & Therapy” This review article discusses recent advances in stem cell-based therapies for Alopecia Areata, noting preliminary clinical trials show significant hair regrowth, but emphasizes the need for thorough evaluation of long-term safety and efficacy.
79 citations
,
December 2013 in “Journal of Investigative Dermatology Symposium Proceedings” This article proposes that alopecia areata may be caused by immune attacks on hair follicles after an immune privilege collapse, suggesting new therapeutic approaches targeting this immune response pattern.
169 citations
,
February 2018 in “Immunity” In this study, researchers found that quiescent stem cells resist immune attack due to downregulated antigen presentation, which may help explain the immune evasion of early cancer-initiating cells.
1 citations
,
March 2025 in “Frontiers in Physiology” This study identified key genes linked to immune cells and potential therapeutic compounds for alopecia areata by evaluating upregulated genes from patient datasets, highlighting T and NK cell involvement in hair follicle attack and suggesting drug candidates through molecular docking and dynamics simulations.
16 citations
,
January 2021 in “Dermatology and therapy” This review discusses the role of gut microbiota in autoimmune and immune-mediated dermatological conditions like lupus and psoriasis, but reports no new clinical results; the authors emphasize the need for further study into microbial signatures and treatments.
3 citations
,
September 2025 in “Neural Regeneration Research” This review discusses the roles of prostaglandins in the nervous system and their therapeutic potential for neurological diseases, noting their complex interactions with immune cells and signaling pathways.
7 citations
,
October 2000 in “Allergo Journal” Stress may affect hair growth by influencing hair follicle development and could contribute to hair loss.
1 citations
,
January 2026 in “Frontiers in Bioengineering and Biotechnology” This review discusses various nanocarriers for gene and genome editing therapies, highlighting that ionizable lipid nanoparticles show advanced delivery performance, while emerging polymer-based and exosome-inspired carriers are rapidly advancing for targeted applications.