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Biomaterials with MSC-derived substances could improve tissue repair and have advantages over direct cell therapy.

Chitosan nanofiber scaffolds improve skin healing and are promising for wound treatment.

Stress-related substance P may lead to hair loss and negatively affect hair growth.

Male and female skin differ due to hormones, affecting conditions like hair loss, acne, and skin cancer, and suggesting a need for gender-specific treatments.

The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.

Alopecia areata is a common autoimmune disease affecting about 2% of people, causing significant disability and often associated with mental health issues and other autoimmune conditions.

Cannabinoids may help treat various skin conditions.

Stem cells in the hair follicle are regulated by their surrounding environment, which is important for hair growth.

A gluten-free diet significantly improves skin and health issues in people with dermatitis herpetiformis, a skin condition linked to celiac disease.

Different types of stem cells exist within individual skin layers, and they can adapt to damage, transplantation, or tumor growth. These cells are regulated by their environment and genetic factors. Tumor growth is driven by expanding, genetically altered cells, not long-lived mutant stem cells. There's evidence of cancer stem cells in skin tumors. Other cells, bacteria, and genetic factors help maintain balance and contribute to disease progression. A method for growing mini organs from single cells has been developed.

Probiotic bacteria improved skin and hair health in aged mice.

Rodent models helped understand psoriasis but none perfectly replicated the disease.

Stress can cause hair loss by negatively affecting hair follicles and this effect might be reversed with specific treatments.

TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.

Skin aging is a complex process influenced by various factors, leading to wrinkles and sagging, and should be considered a disease due to its health impacts.

No single treatment is consistently effective for alopecia areata, and more research is needed.

The telogen phase of hair growth is active and important for preparing hair follicles for regeneration, not just a resting stage.

Men, especially older ones with health issues like prostate cancer, may have worse COVID-19 outcomes and could benefit from therapies targeting male hormones.

Scarless healing is complex and influenced by genetics and environment, while better understanding could improve scar treatment.

Folliculitis decalvans is a rare scalp condition causing scarring hair loss, treated with long-term antibiotics and other medications, but it often comes back and is hard to manage.

Stress increases a factor in mice that leads to hair loss, and blocking this factor may prevent it.

Oral retinoids are effective for various skin conditions but have side effects and should not be used during pregnancy.

The document concludes that hair is complex, with a detailed growth cycle, structure, and clinical importance, affecting various scientific and medical fields.

Skin surface lipids are important for skin health and altering them could help prevent aging and treat skin conditions.

Prolactin affects hair growth and skin conditions, and could be a target for new skin disease treatments.

Smaller nanoemulsions can penetrate skin and hair follicles better, which may be useful for delivering drugs and vaccines through the skin.

Ginseng is possibly safe but its effectiveness is unclear due to poor quality studies and mixed results.

Human hair follicle stem cells can be isolated using specific markers for potential therapeutic use.

The yeast Pityrosporum ovale can cause skin allergies and infections, and antifungal treatments like ketoconazole are effective against it.

Mammals might fail to regenerate not because they lack the right cells, but because of how cells respond to their surroundings, and changing this environment could enhance regeneration.