This case study reports the first known instance of lichen planopilaris being associated with multiple autoimmune syndrome in a woman with hypothyroidism and Crohn's disease.
May 2023 in “Frontiers in veterinary science” This study describes the successful treatment of erythema multiforme in a young Central American tapir with a combination of wound care, silver sulfadiazine cream, and oral prednisolone, emphasizing the importance of diagnostic testing for vesicular dermatitis syndromes in tapirs.
January 2022 in “Journal of Skin and Stem Cell” This review discusses trichodynia, its potential causes, and treatment options, but reports no new clinical findings.
April 2017 in “InTech eBooks” This review discusses potential mechanisms and treatments for trichodynia, noting a lack of strong literature support and reporting no new clinical results; the authors highlight several hypotheses and available treatment options.
April 2003 in “Journal of Cutaneous Medicine and Surgery” Lasers are effective for some skin conditions but can cause side effects like scarring and pigment changes; careful selection is important, and botulinum toxin type A is successful in reducing sweat in palmar hyperhidrosis.
63 citations
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February 2010 in “Journal of Neurophysiology” This study observed that electrical stimulation of specific mechanoreceptive afferents in the orofacial region can evoke sensations consistent with their response properties, while others may require multiple afferents to access perceptual levels.
1 citations
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April 2015 in “Neurology” This study found that hyperpigmented skin changes resembling Schamberg’s purpura occur in areas affected by CRPS and can also appear on mirror-image locations of unaffected limbs, potentially improving with the condition's treatment.
This review discusses advances in understanding tickling sensations and proposes that knismesis hypersensitivity in autism spectrum disorder may be due to impaired sensory integration.
3 citations
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December 2023 in “Pain Medicine” This case report described how peripheral nerve stimulation provided significant pain relief and reversal of dermatological symptoms for a female patient with complex regional pain syndrome after conventional treatments failed.
September 2026 in “International Journal of Dermatology” This review discusses the clinical presentation, diagnosis, and treatment of scalp dysesthesia, highlighting a potential neuropathic component and the inconsistent efficacy of various management strategies without reporting new clinical results.
63 citations
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March 1998 in “Archives of Dermatology” This study describes a new condition called scalp dysesthesia in 11 women, most of whom experienced symptom improvement with low-dose antidepressants.
5 citations
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July 2022 in “Journal of Clinical Medicine” This study found histopathological evidence of hypertrophy in nerve endings that may explain the cutaneous neurosensory symptoms in some long COVID-19 patients.
39 citations
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January 2006 in “Journal of Cosmetic and Laser Therapy” This study found that pneumatic skin flattening (PSF) significantly reduces pain and post-treatment erythema during high-energy IPL and laser hair removal while enhancing treatment efficacy.
1 citations
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June 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” This symposium discussed recent advances in understanding skin as a sensory organ, emphasizing the interactions between itch, pain, and touch pathways and highlighting potential therapeutic targets.
March 2018 in “Journal of Pakistan Association of Dermatology” This study found that using vibration during supraorbital/supratrochlear nerve blocks in hair restoration surgery significantly reduced pain levels compared to not using vibration, with patients reporting lower Wong-Baker Faces Pain scores when vibration was applied.
November 2025 in “Journal of Investigative Dermatology” Keloid fibroblasts cause itch and pain by releasing more histamine.
April 2023 in “IntechOpen eBooks” This review discusses neuropathic pruritus, detailing its clinical presentations and management strategies, but reports no new clinical results.
3 citations
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November 2018 in “PubMed” This study identifies a specific subtype of Telogen Effluvium associated with scalp dysesthesia, such as itch or burning, in the absence of any inflammatory scalp disorder or medication association.
September 2023 in “Journal of the American Academy of Dermatology” This study found that in participants with notalgia paresthetica, 8 weeks of treatment with difelikefalin significantly improved itch intensity and increased the rate of strict complete response compared to placebo, starting as early as week 3.
April 2024 in “Asian Journal of Medical Sciences” This study found that ring block anesthesia was the most acceptable method for reducing pain during platelet-rich plasma injections for hair loss.
3 citations
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February 2002 in “Dermatologic Surgery” Using a handheld massage device during hair transplant significantly reduces pain for most patients.
April 2016 in “Journal of Investigative Dermatology” This study found that administering botulinum toxin A via Flex-PADs to mouse footpads inhibited sweating similarly to traditional injections, suggesting a promising patient-friendly delivery method for hyperhidrosis treatment.
6 citations
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September 2010 in “Archives of Dermatology” This case study suggests that thermography could objectively assess pain severity in herpes zoster patients by correlating thermal images with reported pain intensity.
March 2024 in “Asian journal of medical sciences” In this study, researchers found that a ring block technique was the most accepted anesthesia modality for platelet-rich plasma injections in hair loss treatment, with the least post-procedural pain compared to other methods like vibration anesthesia and nerve blocks.
29 citations
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November 2013 in “Expert Review of Dermatology” This article reviews potential causes and treatments for sensitive skin and reports no new clinical results; the authors emphasize neurogenic inflammation and cosmetic choices as key factors in managing the condition.
January 2012 in “Yearbook of Dermatology and Dermatologic Surgery” Electric current quickly reduces hand sweating but the effect doesn't last long.
5 citations
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July 1999 in “Journal of Anatomy” This study observed that methylene blue staining and zinc iodide-osmium tetroxide techniques effectively revealed anatomical details of intraepidermal nerve fibre endings in the rat's mystacial pad, suggesting their potential role in mechanoreception.
4 citations
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April 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” This study estimates that approximately 230,000 tactile afferent fibers innervate the human body's skin, with varying densities across different regions correlating with spatial acuity and hair follicle density.
7 citations
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April 2019 in “Aesthetic Surgery Journal” This study found that repeated applications of both nonactivated and activated PRP in rats led to increased hypersensitivity to pain, which may be linked to elevated nerve growth factor levels and inflammatory mediators.
2 citations
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August 2024 in “Preprints.org” This case study reports a potential link between ichthyosis and scalp paresthesia, noting that fluocinolone, a synthetic corticosteroid, was effective in reducing paresthesia episodes, suggesting its possible role in the symptomatic treatment of this condition.